Three mixed ligand mononuclear Zn(II) complexes of 4-acyl pyrazolones: Synthesis, characterization, crystal study and anti-malarial activity

被引：32
作者：
Shaikh, Irfan [1 ]
Jadeja, R. N. [1 ]
Patel, Rajesh [2 ]
机构：
[1] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India
[2] Veer Narmad South Gujarat Univ, Dept Biosci, Surat 395007, India
来源：
POLYHEDRON | 2020年 / 183卷
关键词：
Acyl pyrazolone; Antimalarial; Mixed ligand complex; Single crystal; Zinc(II) complexes; DNA-BINDING; PLASMODIUM-FALCIPARUM; COPPER(II) COMPLEXES; CU(II) COMPLEXES; DERIVATIVES; ANTICANCER; BINARY;
D O I：
10.1016/j.poly.2020.114528
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Three novel mixed ligand Zn(II) complexes {complex 1 = [Zn(L1)(2)(bpy)], complex 2 = [Zn(L2)(2)(bPY)], complex 3 = [Zn(L2)(2)(phen)], where bpy = 2,2'-bipyridine and phen = 1,10-phenanthroline} of 4-(4-chlorobenzoyl)-2-(3-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (HL1) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4-dihydro-3H-pyrazol-3-one (HL2) were synthesized and characterized by H-1 and C-13 NMR, FTIR, TG-DTA, UV-Vis, elemental analysis, molar conductance and single crystal X-ray structure determination. Based on analytical and spectroscopic techniques, all the three Zn(II) complexes were found to have a distorted octahedral geometry. The ligands and the complexes were screened for antimalarial activity against plasmodium falciparum. The zinc(II) complexes showed greater antimalarial activity than their parent ligands. (C) 2020 Elsevier Ltd. All rights reserved.
引用
收藏
页数：11
相关论文
共 34 条
  • [1] [Anonymous], PLATON WINDOWS
  • [2] [Anonymous], 1997, SHELXL 97
  • [3] Archibald S. J., 2003, COMPREHENSIVE COORDI, V6, P1147
  • [4] Caraballo Hector, 2014, Emerg Med Pract, V16, P1
  • [5] Evolutionary and historical aspects of the burden of malaria
    Carter, R
    Mendis, KN
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (04) : 564 - +
  • [6] 4-aminoquinoline analogues and its platinum (II) complexes as antimalarial agents
    de Souza, Nicolli Bellotti
    Carmo, Arturene M. L.
    Lagatta, Davi C.
    Martins Alves, Marcio Jose
    Soares Fontes, Ana Paula
    Coimbra, Elaine Soares
    da Silva, Adilson David
    Abramo, Clarice
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2011, 65 (04) : 313 - 316
  • [7] [ZN-3(OH)(2)(1-MEC-N3)(5)(1-MEC-02)(3)(])(4+)(1-MEC=1-METHYLCYTOSINE) - STRUCTURAL MODEL FOR DNA CROSS-LINKING AND DNA REWINDING BY ZN(II)
    FUSCH, EC
    LIPPERT, B
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (16) : 7204 - 7209
  • [8] Hardin CC, 2001, BIOPOLYMERS, V56, P147, DOI 10.1002/1097-0282(2000/2001)56:3<147::AID-BIP10011>3.0.CO
  • [9] 2-N
  • [10] Synthesis, structures, and antimalarial activities of some silver(I), gold(I) and gold(III) complexes involving N-heterocyclic carbene ligands
    Hemmert, Catherine
    Fabie, Aymeric
    Fabre, Aude
    Benoit-Vical, Francoise
    Gornitzka, Heinz
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 60 : 64 - 75
1234