HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

被引：144

作者：

Miotto, Benoit ^{[1
]}

Struhl, Kevin ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 19期

基金：

美国国家卫生研究院;

关键词：

HBO1; DNA replication; Cdt1; origin licensing; histone acetylation; Geminin;

D O I：

10.1101/gad.1674108

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. HBO1 directly interacts with Cdt1, and it enhances Cdt1-dependent rereplication. Thus, HBO1 plays a direct role at replication origins as a coactivator of the Cdt1 licensing factor. As HBO1 is also a transcriptional coactivator, it has the potential to integrate internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication.

引用

页码：2633 / 2638

页数：6

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