Two-stage sample size re-estimation based on a nuisance parameter: A review

被引：59

作者：

Proschan, MA ^{[1
]}

机构：

[1] NHLBI, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOPHARMACEUTICAL STATISTICS | 2005年 / 15卷 / 04期

关键词：

adaptive methods; ancillary statistic; blinding; continuous outcome; clinical trials; conditioning; correlation; dichotomous outcome; independence; internal pilot study; lumping; pooling; power; restricted design; unrestricted design;

D O I：

10.1081/BIP-200062852

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sample size calculations are important and difficult in clinical trails because they depend on the nuisance parameter and treatment effect. Recently, much attention has been focused on two-stage methods whereby the first stage constitutes an internal pilot study used to estimate parameters and revise the final sample size. This paper reviews two-stage methods based on estimation of nuisance parameters in either a continuous or dichotomous outcome setting.

引用

页码：559 / 574

页数：16

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