Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines

被引：65
|
作者：
Vaddula, Buchi Reddy [1 ]
Varma, Rajender S. [1 ]
Leazer, John [1 ]
机构：
[1] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 12期
关键词：
1,3-Diketones; Aryl hydrazines; Aryl hydrazides; Catalyst-free; Condensation; ROOM-TEMPERATURE SYNTHESIS; EFFICIENT SYNTHESIS; REUSABLE CATALYST; DERIVATIVES; ENAMINONES; ACID;
D O I：
10.1016/j.tetlet.2013.01.029
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and facile condensation of hydrazines/hydrazides and diamines with 1,3-diketones/beta-ketoester leads to the preparation of pyrazoles and diazepines in high yields. This eco-friendly protocol is accelerated by microwave heating and efficiently carried out without any reaction solvent or catalyst in as little as 5 min. Published by Elsevier Ltd.
引用
收藏
页码：1538 / 1541
页数：4
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