Synthesis and in vitro Anticancer Activity of Novel Heterocycles Utilizing Thiophene Incorporated Thioureido Substituent as Precursors

被引：4

作者：

Abdel-Motaal, Marwa ^{[1
,2
]}

Alanzy, Asmaa L. ^{[2
]}

Asem, Medhat ^{[3
]}

机构：

[1] Qassim Univ, Coll Sci, Dept Chem, Buridah, Qassim, Saudi Arabia

[2] Mansoura Univ, Fac Sci, Dept Chem, ET-35516 Mansoura, Egypt

[3] Menoufia Univ, Fac Sci, Biochem, Menoufia, Egypt

来源：

ACTA CHIMICA SLOVENICA | 2020年 / 67卷 / 02期

关键词：

Tetrahydrobenzo[b]thiophene; thiourea substituent; heterocycles; anticancer activity; ANTIINFLAMMATORY ACTIVITY; DERIVATIVES; DESIGN; THIAZOLE; DOCKING; POTENT;

D O I：

10.17344/acsi.2019.5571

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ethyl 2-(3-allylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (1) was used as a building block for synthesis of new heterocycles. Pyrimidine and thiazole moieties were achieved upon condensation of compound 1 with various reagents such as chloroacetic acid, dietyl malonate, ninhydrin, 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone, and hydrazine hydrate. The structures of the newly synthesized compounds were confirmed using spectral measurements. The prepared products were evaluated for their anticancer activity against colon HCT-116 human cancer cell line. Compounds 6, 9, 10a, 11, 12, 15 have displayed potent activity.

引用

页码：560 / 569

页数：10

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