The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds

被引：26

作者：

Liu, Ye ^{[1
,2
]}

Mao, Yujian ^{[1
,2
]}

Hu, Yanwei ^{[1
,2
]}

Gui, Jingjing ^{[1
,2
]}

Wang, Liang ^{[3
]}

Wang, Wei ^{[4
,5
,6
,7
]}

Zhang, Shilei ^{[1
,2
]}

机构：

[1] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

[3] Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Shandong, Peoples R China

[4] East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China

[5] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

[6] Univ Arizona, Dept Pharmacol & Toxicol, 1703 E Mabel St,POB 210207, Tucson, AZ 85721 USA

[7] Univ Arizona, BIO5 Inst, 1703 E Mabel St,POB 210207, Tucson, AZ 85721 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 07期

基金：

中国国家自然科学基金;

关键词：

sodium hydride; palladium catalysis; Michael donor; 1,4-conjugate reduction; alpha; beta-unsaturated carbonyl compounds; TRANSFER HYDROGENATION; CONJUGATE REDUCTION; CYCLIZATION; HYDRODEHALOGENATION; CONSTRUCTION; CHLORIDES; OLEFINS; ESTER; ACID;

D O I：

10.1002/adsc.201801676

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of alpha, beta-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules.

引用

页码：1554 / 1558

页数：5

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