First direct C-2-lithiation of 4-DMAP. Convenient access to reactive functional derivatives and ligands

被引：70

作者：

Cuperly, D ^{[1
]}

Gros, P ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Nancy 1, Fac Sci, CNRS UHP, UMR 7565, F-54506 Vandoeuvre Les Nancy, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 01期

关键词：

D O I：

10.1021/jo016064p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first direct alpha-lithiation of 4-DMAP has been peformed via reaction with the BuLi-Me2N(CH2)(2)-OLi (BuLi-LiDMAE) reagent. This new methodology avoids the use of a activation-lithiation-regeneration sequence or halogen-metal exchange classically employed. New useful DMAP-containing synthons and polyheterocycles have been efficiently prepared.

引用

页码：238 / 241

页数：4

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