Colorimetric Chemosensor for Chloramphenicol Based on Colloidal Magnetically Assembled Molecularly Imprinted Photonic Crystals

A novel colorimetric chemosensor with good sensitivity, specificity, and self-reporting capability for chloramphenicol (CAP) has been successfully constructed based on colloidal, magnetically assembled photonic crystals coupled with molecular imprinting. The colloidal, magnetically assembled, molecularly imprinted photonic crystals (CMA-MIPCs) were prepared by assembling CAP in magnetic, molecularly imprinted nanohydrogels (MMIHs) in a magnetic field. The magnetic assembly of photonic crystals and the sensing processes could be completed simultaneously when MMIHs were dispersed in CAP solutions and in a magnetic field, and the response time was less than 1 min. The CAP concentration could be visually determined from the color change of the CMA-MIPCs sensor. The diffraction color blue-shifted from luminous yellow of the blank to purple in a 1.0 mg/mL CAP solution, with a determination limit of 1.0 x 10(-3) mg/mL. It could provide a new strategy for qualitative or semiquantitative detection of CAP.