Measurement of cephalexin partition coefficients in PEG + K2HPO4 + H2O aqueous two-phase systems at 301.15, 306.15 and 311.15 K

被引：7

作者：

Doozandeh, Sara Ghayour ^{[2
]}

Pazuki, Gholamreza ^{[1
]}

Madadi, Babak ^{[1
]}

Rohani, Ali Asghar ^{[2
]}

机构：

[1] Amirkabir Univ Technol, Dept Chem Engn, Tehran, Iran

[2] Islamic Azad Univ, Dept Chem Engn, Shahrood Branch, Shahrood, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2012年 / 174卷

关键词：

LLE data; Aqueous two-phase systems; Partitioning; PEG; K2HPO4; Cephalexin; AQUEOUS 2-PHASE SYSTEMS; DIPOTASSIUM HYDROGEN PHOSPHATE; POLY(ETHYLENE GLYCOL); DIFFERENT TEMPERATURES; POLYETHYLENE-GLYCOL; SODIUM-CITRATE; BETA-AMYLASE; PENICILLIN-G; AMINO-ACIDS; SALT;

D O I：

10.1016/j.molliq.2012.07.026

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, the liquid-liquid equilibrium (LLE) data for poly(ethylene glycol) with molecular weights 1500 and 6000 - K2HPO4 aqueous two-phase systems containing cephalexin antibiotic have been measured at three temperatures 301.15, 306.15 and 311.15 K. The effects of temperature. PEG molecular weight and concentrations of PEG and salt have been studied on the LLE data. Also, the partitioning of cephalexin in PEG-salt aqueous two-phase systems has been estimated using the LLE data. The experimental data showed that the concentration of salt has a large effect on the partitioning of cephalexin in aqueous two-phase systems. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：95 / 99

页数：5

共 50 条

[1] Measurement and Correlation of Partition Coefficients of Glycyrrhizic in Aqueous Two-phase EOPO/K2HPO4 Systems
Huo, Qing
Lin, Qiang
Gao, Wei
Li, Haixia
ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (06) : 4496 - 4500
[2] Distribution of Puerarin in Aqueous Two-Phase EOPO/K2HPO4/Water Systems
Huo, Qing
Gao, Wei
ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (04) : 2235 - 2238
[3] Measurement and Correlation of the Phase Diagram Data for PPG400 + (K3PO4, K2CO3, and K2HPO4) + H2O Aqueous Two-Phase Systems at T=298.15 K
Xie, Xueqiao
Han, Juan
Wang, Yun
Yan, Yongsheng
Yin, Guowu
Guan, Weisheng
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2010, 55 (11): : 4741 - 4745
[4] Partition coefficients of α-amylase in aqueous two-phase systems PEG+MgSO4•7H2O+H2O at 298K
Blázquez, G
Camacho, F
González-Tello, P
Alarcón, FJ
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1998, 1379 (02): : 191 - 197
[5] Partition coefficients of a-amylase in aqueous two-phase systems PEG+MgSO4 QQ 7H2O+H2O at 298 K
Blazquez, G.
Camacho, F.
Gonzalez-Tello, P.
Alarcon, F. J.
B B A - Biomembranes, 1379 (02):
[6] Measurement and Correlation of Equilibrium Data for Aqueous Two-phase System Ethanol+Water+ K2HPO4
LIN Jin-qing*
ChemicalResearchinChineseUniversities, 2004, (02) : 195 - 199
[7] Vibrational behaviour of K2HPO4, K2HPO4•3H2O and their deuterated derivatives with temperature
Hadrich, A
Lautié, A
Mhiri, T
Romain, F
VIBRATIONAL SPECTROSCOPY, 2001, 26 (01) : 51 - 64
[8] Measurement and correlation of equilibrium data for aqueous two-phase system ethanol plus water plus K2HPO4
Lin, JQ
Tan, PH
Jin, CY
Li, MC
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2004, 20 (02) : 195 - 199
[9] Partition coefficients of flavonols in the poly(ethylene glycol)-K2HPO4-water aqueous two-phase system
Mishima, K
Ezawa, M
Yamauchi, S
Uchiyama, H
Ito, M
Ouchi, M
Hakushi, T
SOLVENT EXTRACTION RESEARCH AND DEVELOPMENT-JAPAN, 1999, 6 : 168 - 175
[10] Measurement and Correlation of Phase Diagram Data for Aqueous Two-Phase Systems Containing 1-Ethyl-3-methylimidazolium Dimethyl Phosphate + K3PO4/K2HPO4/K2CO3 + H2O Ionic Liquids at (298.15, 308.15, and 318.15) K
Wang, Liang
Zhu, Hong
Ma, Chunhong
Yan, Yongsheng
Wang, Qingwei
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2012, 57 (03): : 681 - 687

← 1 2 3 4 5 →