Treatment interruption in chronic HIV-1 infection: does it deliver?

被引：1
作者：
Willberg, Christian B. [1 ]
Nixon, Douglas F. [1 ]
机构：
[1] UCSF, Div Expt Med, San Francisco, CA 94110 USA
来源：
CURRENT OPINION IN HIV AND AIDS | 2007年 / 2卷 / 01期
关键词：
chronic infection; highly active antiretroviral therapy; HIV-1; treatment interruption;
D O I：
10.1097/COH.0b013e3280119307
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Purpose of review This review sets out to overview treatment interruption in chronic HIV-1 infection: what treatment interruption promised, results from recent trials, and what the future holds. Recent findings Recent studies have produced mixed results; several trials have been prematurely halted, whereas others have reported more positive outcomes. One consistent finding has been the identification of the CD4 T-cell count nadir as a critical parameter in determining the outcome of treatment interruption. Summary The use of treatment interruption is still controversial, but it is becoming clear that certain individuals could benefit, and partial treatment interruption strategies warrant further investigation.
引用
收藏
页码：26 / 30
页数：5
相关论文
共 50 条
  • [1] Treatment interruption for virological failure or as sparing regimen in children with chronic HIV-1 infection
    Monpoux, F
    Tricoire, J
    Lalande, M
    Reliquet, V
    Bebin, B
    Thuret, I
    AIDS, 2004, 18 (18) : 2401 - 2409
  • [2] Peptide-loaded dendritic-cell vaccination followed by treatment interruption for chronic HIV-1 infection: A phase 1 trial
    Ide, F
    Nakamura, T
    Tomizawa, M
    Kawana-Tachikawa, A
    Odawara, T
    Hosoya, N
    Iwamoto, A
    JOURNAL OF MEDICAL VIROLOGY, 2006, 78 (06) : 711 - 718
  • [3] Treatment interruption after early-treated perinatal HIV-1 infection
    Luzuriaga, Katherine
    Persaud, Deborah
    AIDS, 2016, 30 (15) : 2381 - 2383
  • [4] Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection
    Sandgaard, Katrine Schou
    Margetts, Ben
    Attenborough, Teresa
    Gkouleli, Triantafylia
    Adams, Stuart
    Holm, Mette
    Gibb, Diana
    Gibbons, Deena
    Giaquinto, Carlo
    De Rossi, Anita
    Bamford, Alasdair
    Palma, Paolo
    Chain, Benny
    Gkazi, Athina S.
    Klein, Nigel
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [5] Evaluating lncRNA Expression Patterns during HIV-1 Treatment Interruption
    Schynkel, Tinus
    van Snippenberg, Willem
    Van Hecke, Clarissa
    Vandekerckhove, Linos
    Trypsteen, Wim
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (02)
  • [6] Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection
    Gisslén M.
    Rosengren L.
    Hagberg L.
    Deeks S.G.
    Price R.W.
    AIDS Research and Therapy, 2 (1)
  • [7] Antiretroviral treatment of HIV-1 infection
    Stellbrink, H. -J.
    INTERNIST, 2012, 53 (10): : 1157 - +
  • [8] Controversies in the treatment of HIV-1 infection
    Kinloch-de Loes, Sabine
    INFECTIONS IN MEDICINE, 2007, 24 (08) : 335 - 338
  • [9] Dynamic range of Nef functions in chronic HIV-1 infection
    Mwimanzi, Philip
    Markle, Tristan J.
    Ogata, Yoko
    Martin, Eric
    Tokunaga, Michiyo
    Mahiti, Macdonald
    Kuang, Xiaomei T.
    Walker, Bruce D.
    Brockman, Mark A.
    Brumme, Zabrina L.
    Ueno, Takamasa
    VIROLOGY, 2013, 439 (02) : 74 - 80
  • [10] Epigenetic crosstalk in chronic infection with HIV-1
    Ulrike C Lange
    Roxane Verdikt
    Amina Ait-Ammar
    Carine Van Lint
    Seminars in Immunopathology, 2020, 42 : 187 - 200
12345