Cycloartane Triterpenes and Ingol Diterpenes Isolated from Euphorbia neriifolia in a Screening Program for Death-Receptor Expression-Enhancing Activity

被引：33

作者：

Toume, Kazufumi

Nakazawa, Takafumi

Hoque, Tahmina

Ohtsuki, Takashi

Arai, Midori A.

Koyano, Takashi ^{[2
]}

Kowithayakorn, Thaworn ^{[3
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Temko Corp, Tokyo, Japan

[3] Khon Kaen Univ, Fac Agr, Chiba, Japan

来源：

PLANTA MEDICA | 2012年 / 78卷 / 12期

基金：

日本学术振兴会;

关键词：

Euphorbia neriifolia; Euphorbiaceae; cycloartane triterpene; ingol diterpene; death receptor; TRAIL; TRAIL; APOPTOSIS; SEARCH; LATEX;

D O I：

10.1055/s-0032-1314975

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In our screening program for natural products that increase death-receptor 5 expression, seven new cycloartane triterpenes, euphonerins A-G (1-7), and 3-O-acetyl-8-O-tigloylingol (8), a new ingol diterpene, were isolated from the MeOH extract of Euphorbia neriifolia leaves, together with 3,12-di-O-acetyl-8-O-tigloylingol (9), (24R)-cycloartane-3 beta,24,25-triol (10), and three known flavonols (11-13). The structures of 1-8 were elucidated by spectroscopic analysis. Among these compounds, 1-11 showed death-receptor 5 expression enhancing activity.

引用

页码：1370 / 1377

页数：8

共 22 条

[11] The combination of TRAIL and luteolin enhances apoptosis in human cervical cancer HeLa cells [J].