Single-nucleotide polymorphisms in human β-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters

被引：31

作者：

Baroncelli, Silvia ^{[1
]}

Ricci, Elisabetta ^{[2
]}

Andreotti, Mauro ^{[1
]}

Guidotti, Giovanni ^{[1
]}

Germano, Paola ^{[3
]}

Marazzi, Maria Cristina ^{[4
]}

Vella, Stefano ^{[1
]}

Palombi, Leonardo ^{[5
]}

De Rossi, Anita ^{[2
]}

Giuliano, Marina ^{[1
]}

机构：

[1] Ist Super Sanita, Pharmacol & Therapy Viral Dis Unit, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy

[2] Univ Padua, AIDS Reference Ctr, Dept Oncol & Surg Sci, Padua, Italy

[3] Community St Egidio, DREAM Program, Rome, Italy

[4] Libera Univ Maria SS Assunta, DREAM Program, Rome, Italy

[5] Univ Roma Tor Vergata, Dept Publ Hlth, DREAM Program, Rome, Italy

来源：

AIDS | 2008年 / 22卷 / 12期

关键词：

D O I：

10.1097/QAD.0b013e3282fd6e0c

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.

引用

页码：1515 / 1517

页数：3

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