Eculizumab in the treatment of neuromyelitis optica spectrum disorder

被引：4

作者：

Giglhuber, Katrin ^{[1
]}

Berthele, Achim ^{[1
]}

机构：

[1] Tech Univ Munich, Sch Med, Dept Neurol, Klinikum Rechts Isar, Ismaninger Str 22, D-81675 Munich, Germany

来源：

IMMUNOTHERAPY | 2020年 / 12卷 / 14期

关键词：

antibody therapeutics; autoimmunity; complement system; immunotherapy; neuromyelitis optica; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; DIAGNOSTIC-CRITERIA; DOUBLE-BLIND; PHASE-3; EFFICACY; SAFETY; SATRALIZUMAB; MULTICENTER; BINDING; MARKER;

D O I：

10.2217/imt-2020-0163

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease of the CNS which is distinct from multiple sclerosis and typically presents with a relapsing course of optic neuritis, myelitis and midline brain inflammatory lesions. In at least two-thirds of cases, antibodies against the water channel AQP4 can be found, which lead to an antibody-mediated activation of the complement system with consecutive damage to neuronal structures. Eculizumab, a humanized monoclonal antibody against the terminal complement component 5, was shown to significantly reduce the risk of NMOSD relapse in a Phase III placebo-controlled trial. Based on this, eculizumab (Soliris(R)) was the first drug to be formally approved for the treatment of anti-AQP4-antibody positive NMOSD in 2019.

引用

页码：1053 / 1066

页数：14

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