Synthesis and biological activities of 8-arylflavones

被引：30
作者：
Dao, TT
Kim, SB
Sin, KS
Kim, S
Kim, HP
Park, H [1 ]
机构：
[1] Kangweon Natl Univ, Coll Pharm, Chunchon 200701, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 03期
关键词：
8-arylflavones; COX-2; prostaglandin production inhibition; anti-inflammatory activity; Suzuki reaction; carbon-carbon coupling reaction;
D O I：
10.1007/BF02980059
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A number of 8-arylflavones have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE(2) production. 8-Arylflavones were obtained from commercially available chrysin via two different synthetic pathways. Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed PGE(2) production compared to that of wogonin. Functional group replacement at the 8-position of wogonin from methoxy to aryl group caused loss of inhibitory activity. Our present results imply that the functional group at the 8-position of flavones seems to play very important roles for bioactivity.
引用
收藏
页码：278 / 282
页数：5
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