Synthesis and biological activities of 8-arylflavones

被引：30

作者：

Dao, TT

Kim, SB

Sin, KS

Kim, S

Kim, HP

Park, H ^{[1
]}

机构：

[1] Kangweon Natl Univ, Coll Pharm, Chunchon 200701, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 03期

关键词：

8-arylflavones; COX-2; prostaglandin production inhibition; anti-inflammatory activity; Suzuki reaction; carbon-carbon coupling reaction;

D O I：

10.1007/BF02980059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of 8-arylflavones have been synthesized as congeners of wogonin and evaluated for their inhibitory activities of PGE(2) production. 8-Arylflavones were obtained from commercially available chrysin via two different synthetic pathways. Most 8-arylflavones exhibited much reduced inhibitory activities against COX-2 catalyzed PGE(2) production compared to that of wogonin. Functional group replacement at the 8-position of wogonin from methoxy to aryl group caused loss of inhibitory activity. Our present results imply that the functional group at the 8-position of flavones seems to play very important roles for bioactivity.

引用

页码：278 / 282

页数：5

共 14 条

[1]

[Anonymous], 1983, J IMMUNOL METH

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