Water-soluble Re6-clusters with aromatic phosphine ligands - from synthesis to potential biomedical applications

被引：38

作者：

Ivanov, Anton A. ^{[1
,2
]}

Konovalov, Dmitry L. ^{[1
,3
]}

Pozmogova, Tatiana N. ^{[2
,3
,4
]}

Solovieva, Anastasiya O. ^{[2
,3
]}

Melnikov, Anatoly R. ^{[3
,5
]}

Brylev, Konstantin A. ^{[1
,3
]}

Kuratieva, Natalia, V ^{[1
,3
]}

Yanshole, Vadim V. ^{[3
,6
]}

Kirakci, Kaplan ^{[7
]}

Lang, Kamil ^{[7
]}

Cheltygmasheva, Svettana N. ^{[2
]}

Kitamura, Noboru ^{[8
]}

Shestopalova, Lidiya, V ^{[3
]}

Mironove, Yuri, V ^{[1
,3
]}

Shestopalov, Michael A. ^{[1
,2
,3
,4
]}

机构：

[1] Nikolaev Inst Inorgan Chem SB RAS, 3 Acad Lavrentiee Ave, Novosibirsk 630090, Russia

[2] Fed Res Ctr Fundamental & Translat Med, 2 Timakova Str, Novosibirsk 630117, Russia

[3] Novosibirsk State Univ, 2 Pirogova Str, Novosibirsk 630090, Russia

[4] Branch ICG SB RAS, Sci Inst Clin & Expt Lymphol, 2 Timakova Str, Novosibirsk 630060, Russia

[5] Voevodsky Inst Chem Kinet & Combust SB RAS, 3 Inst Skaya St, Novosibirsk 630090, Russia

[6] Int Tomog Ctr SB RAS, 3a Inst Skaya St, Novosibirsk 630090, Russia

[7] Czech Acad Sci, Inst Inorgan Chem, Husinec Rez 1001, Rez 25068, Czech Republic

[8] Hokkaido Univ, Fac Sci, Dept Chem, Sapporo, Hokkaido 0600810, Japan

来源：

INORGANIC CHEMISTRY FRONTIERS | 2019年 / 6卷 / 04期

基金：

俄罗斯科学基金会;

关键词：

RHENIUM CLUSTER COMPLEXES; CORE-CONTAINING CLUSTERS; STRUCTURAL-CHARACTERIZATION; SUPRAMOLECULAR ARRAYS; HEXARHENIUM(III) CLUSTERS; CELLULAR INTERNALIZATION; CRYSTAL-STRUCTURE; BUILDING-BLOCKS; ORGANIC-LIGANDS; BASIS-SET;

D O I：

10.1039/c8qi01216d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy. Herein, we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands, and delineate their photoluminescence and X-ray excited optical luminescence (XEOL) properties. These cluster complexes, namely [{Re(6)Q(8)}(PPh2CH2CH2COO)(6)](4-)(Q = S (1); Se, (2)), have the least cytotoxicity among all the tested hexanuclear metal-clusters, are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.

引用

页码：882 / 892

页数：11

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