A new perspective: Exploring future therapeutic strategies for cancer by understanding the dual role of B lymphocytes in tumor immunity

被引：27
|
作者：
Liu, Min [1 ,2 ,3 ,4 ,5 ]
Sun, Qian [1 ,2 ,3 ,4 ,5 ]
Wang, Jian [1 ,2 ,3 ,4 ,5 ]
Wei, Feng [1 ,2 ,3 ,4 ,5 ]
Yang, Lili [1 ,2 ,3 ,4 ,5 ]
Ren, Xiubao [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Immunol, Tianjin, Peoples R China
[2] Natl Clin Res Ctr Canc, Tianjin, Peoples R China
[3] Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
[4] Tianjins Clin Res Ctr Canc, Tianjin, Peoples R China
[5] Key Lab Canc Immunol & Biotherapy, Tianjin, Peoples R China
[6] Tianjin Med Univ, Dept Biotherapy, Canc Inst & Hosp, Tianjin, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CANCER | 2019年 / 144卷 / 12期
基金：
中国国家自然科学基金;
关键词：
B lymphocytes; regulatory B cells; tumor immunity; prognosis; immunotherapy; TERTIARY LYMPHOID STRUCTURES; INFILTRATING PLASMA-CELLS; MEDULLARY BREAST-CANCER; IMMUNOGLOBULIN-KAPPA C; CD4(+) T-CELLS; GRANZYME-B; ANTITUMOR IMMUNITY; PROGNOSTIC IMPACT; B-1; CELLS; EXPRESSION;
D O I：
10.1002/ijc.31850
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our previous understanding of the role of B lymphocytes in tumor immunity is its antitumor effects. However, further evidence indicates B lymphocytes can also promote tumorigenesis by modulating immune responses. Therefore, the increasingly complex role of B lymphocytes in tumor immunity may become an important factor in tumor immunotherapy. In this review, we describe the development of B cells in tumor microenvironments. We then focus on the most controversial issues of the biological functions of B lymphocytes. Finally, we nominate B cells as therapeutic targets, which should open broad perspectives for the development of their clinical applications.
引用
收藏
页码：2909 / 2917
页数：9
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