Algorithm-Based Prediction of HIV-1 Subtype D Coreceptor Use

被引：4

作者：

Dina, Julia ^{[1
]}

Raymond, Stephanie ^{[2
]}

Maillard, Anne ^{[3
]}

Le Guillou-Guillemette, Helene ^{[4
]}

Rodalec, Audrey ^{[5
]}

Beby-Defaux, Agnes ^{[6
]}

Giraudeau, Genevieve ^{[6
]}

Vallet, Sophie ^{[7
]}

Mourez, Thomas ^{[8
]}

Payan, Christopher ^{[7
]}

Vabret, Astrid ^{[1
]}

Ruffault, Annick ^{[3
]}

Ferre, Virginie ^{[5
]}

Izopet, Jacques ^{[2
]}

Plantier, Jean-Christophe ^{[8
]}

机构：

[1] CHU Caen, Virol Lab, F-14000 Caen, France

[2] CHU Toulouse, Virol Lab, Toulouse, France

[3] CHU Rennes, Virol Lab, Rennes, France

[4] CHU Angers, Virol Lab, Angers, France

[5] CHU Nantes, Virol Lab, F-44035 Nantes 01, France

[6] CHU Poitiers, Virol Lab, Poitiers, France

[7] CHU Brest, Virol Lab, F-29285 Brest, France

[8] CHU Rouen, Virol Lab, Rouen, France

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 09期

关键词：

GENOTYPIC PREDICTION; TROPISM;

D O I：

10.1128/JCM.00798-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.

引用

页码：3087 / 3089

页数：3

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