Inflammaging: Implications in Sarcopenia

被引:105
作者
Antuna, Eduardo [1 ,2 ,3 ]
Cachan-Vega, Cristina [1 ,2 ,3 ]
Carlos Bermejo-Millo, Juan [1 ,2 ,3 ]
Potes, Yaiza [1 ,2 ,3 ]
Caballero, Beatriz [1 ,2 ,3 ]
Vega-Naredo, Ignacio [1 ,2 ,3 ]
Coto-Montes, Ana [1 ,2 ,3 ]
Garcia-Gonzalez, Claudia [1 ,2 ,3 ]
机构
[1] Inst Invest Sanitaria Principado Asturias ISPA, Av Hosp Univ, Oviedo 33011, Spain
[2] Univ Oviedo, Dept Morphol & Cell Biol, Oviedo 33006, Spain
[3] Inst Neurociencias Principado Asturias INEUROPA, Oviedo 33006, Spain
关键词
inflammation; aging; sarcopenia; skeletal muscle; TUMOR-NECROSIS-FACTOR; SKELETAL-MUSCLE REGENERATION; ADIPOSE-TISSUE; INSULIN-RESISTANCE; SENESCENT CELLS; SATELLITE CELLS; OLDER-ADULTS; FACTOR-ALPHA; CROSS-TALK; SYSTEMIC INFLAMMATION;
D O I
10.3390/ijms232315039
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as "inflammaging" is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging, correlations between these two terms have been proposed. Better knowledge of the immune system players in skeletal muscle would help to elucidate their implications in sarcopenia. Characterizing the activators of damage sensors and the downstream effectors explains the inference with skeletal muscle performance. Sarcopenia has also been linked to chronic diseases such as diabetes, metabolic syndrome and obesity. Implications of inflammatory signals from these diseases negatively affect skeletal muscle. Autophagic mechanisms are closely related with the inflammasome, as autophagy eliminates stress signaling sent by damage organelles, but also acts with an immunomodulatory function affecting immune cells and cytokine release. The use of melatonin, an antioxidant, ROS scavenger and immune and autophagy modulator, or senotherapeutic compounds targeting senescent cells could represent strategies to counteract inflammation. This review aims to present the many factors regulating skeletal muscle inflammaging and their major implications in order to understand the molecular mechanisms involved in sarcopenia.
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页数:24
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共 233 条
[1]   Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency [J].
Alberro, Ainhoa ;
Iribarren-Lopez, Andrea ;
Saenz-Cuesta, Matias ;
Matheu, Ander ;
Vergara, Itziar ;
Otaegui, David .
SCIENTIFIC REPORTS, 2021, 11 (01)
[2]   Amelioration of diabetes-induced inflammation mediated pyroptosis, sarcopenia, and adverse muscle remodelling by bone morphogenetic protein-7 [J].
Aluganti Narasimhulu, Chandrakala ;
Singla, Dinender K. .
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2021, 12 (02) :403-420
[3]   Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans [J].
Anderson, Ethan J. ;
Lustig, Mary E. ;
Boyle, Kristen E. ;
Woodlief, Tracey L. ;
Kane, Daniel A. ;
Lin, Chien-Te ;
Price, Jesse W., III ;
Kang, Li ;
Rabinovitch, Peter S. ;
Szeto, Hazel H. ;
Houmard, Joseph A. ;
Cortright, Ronald N. ;
Wasserman, David H. ;
Neufer, P. Darrell .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (03) :573-581
[4]   Immunosenescence: emerging challenges for an ageing population [J].
Aw, Danielle ;
Silva, Alberto B. ;
Palmer, Donald B. .
IMMUNOLOGY, 2007, 120 (04) :435-446
[5]   Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging [J].
Baar, Marjolein P. ;
Brandt, Renata M. C. ;
Putavet, Diana A. ;
Klein, Julian D. D. ;
Derks, Kasper W. J. ;
Bourgeois, Benjamin R. M. ;
Stryeck, Sarah ;
Rijksen, Yvonne ;
van Willigenburg, Hester ;
Feijtel, Danny A. ;
van der Pluijm, Ingrid ;
Essers, Jeroen ;
van Cappellen, Wiggert A. ;
van IJcken, Wilfred F. ;
Houtsmuller, Adriaan B. ;
Pothof, Joris ;
de Bruin, Ron W. F. ;
Madl, Tobias ;
Hoeijmakers, Jan H. J. ;
Campisi, Judith ;
de Keizer, Peter L. J. .
CELL, 2017, 169 (01) :132-+
[6]   Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps [J].
Baczek, Jan ;
Silkiewicz, Marta ;
Wojszel, Zyta Beata .
NUTRIENTS, 2020, 12 (08) :1-22
[7]   Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders [J].
Baker, Darren J. ;
Wijshake, Tobias ;
Tchkonia, Tamar ;
LeBrasseur, Nathan K. ;
Childs, Bennett G. ;
van de Sluis, Bart ;
Kirkland, James L. ;
van Deursen, Jan M. .
NATURE, 2011, 479 (7372) :232-U112
[8]   Age-dependent alteration in muscle regeneration: the critical role of tissue niche [J].
Barberi, Laura ;
Scicchitano, Bianca Maria ;
De Rossi, Manuela ;
Bigot, Anne ;
Duguez, Stephanie ;
Wielgosik, Aurore ;
Stewart, Claire ;
McPhee, Jamie ;
Conte, Maria ;
Narici, Marco ;
Franceschi, Claudio ;
Mouly, Vincent ;
Butler-Browne, Gillian ;
Musaro, Antonio .
BIOGERONTOLOGY, 2013, 14 (03) :273-292
[9]   Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies [J].
Batsis, John A. ;
Villareal, Dennis T. .
NATURE REVIEWS ENDOCRINOLOGY, 2018, 14 (09) :513-537
[10]   Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people [J].
Baylis, D. ;
Bartlett, D. B. ;
Syddall, H. E. ;
Ntani, G. ;
Gale, C. R. ;
Cooper, C. ;
Lord, J. M. ;
Sayer, A. A. .
AGE, 2013, 35 (03) :963-971