A New Approach to Inotropic Therapy in the Treatment of Heart Failure Cardiac Myosin Activators in Treatment of HF

被引：11

作者：

Garg, Vinisha ^{[1
]}

Frishman, William H. ^{[2
]}

机构：

[1] UCLA Sch Med & Hosp, Dept Med, Los Angeles, CA USA

[2] New York Med Coll, Dept Med, Westchester Med Ctr, Valhalla, NY 10595 USA

来源：

CARDIOLOGY IN REVIEW | 2013年 / 21卷 / 03期

关键词：

cardiac myosin activator; omecamtiv mecarbil; CK-1827452; systolic ejection time; heart failure; inotrope; OMECAMTIV MECARBIL; CONSCIOUS DOGS; MILRINONE; AGENTS;

D O I：

10.1097/CRD.0b013e318275889c

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systolic heart failure remains a leading cause of death and disability, and available pharmacologic treatments for heart failure are limited in both safety and effectiveness. Existing drugs focus on diverse mechanisms related to the pathophysiology of heart failure, yet none directly target the central feature of systolic heart failure, decreased cardiac contractility. Cardiac myosin activators, specifically omecamtiv mecarbil (formerly CK-1827452), directly activate the enzymatic pathway within the cardiac myocyte leading to ventricular contraction. This unique inotropic agent has been shown in preclinical and clinical studies to be effective in improving cardiac contractility by increasing systolic ejection time without the unwanted effects of the currently available indirect inotropic drugs. Cardiac myosin activators show great promise and may prove to be a safer and more effective therapeutic approach for the treatment of systolic heart failure.

引用

页码：155 / 159

页数：5

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