Sinus node dysfunction: An adverse effect of lacosamide

被引：40

作者：

Chinnasami, Suganthi ^{[1
]}

Rathore, Chaturbhuj ^{[1
]}

Duncan, John S. ^{[1
]}

机构：

[1] Natl Hosp Neurol & Neurosurg, Dept Clin & Expt Epilepsy, London WC1N 3BG, England

来源：

EPILEPSIA | 2013年 / 54卷 / 06期

关键词：

Lacosamide; Sinus node dysfunction; Adverse effects; PARTIAL-ONSET SEIZURES; ATRIOVENTRICULAR-BLOCK; ADJUNCTIVE THERAPY; EFFICACY; SAFETY; TRIAL;

D O I：

10.1111/epi.12108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lacosamide, a recently introduced antiepileptic drug, acts by enhancing the slow inactivation of voltage-dependent sodium channels. Cardiac conduction disturbances, namely atrial fibrillation and atrioventricular block, have been reported in patients with epilepsy. We report a patient with drug-resistant focal epilepsy who developed asymptomatic sinus node dysfunction following lacosamide use, which resolved on stopping lacosamide. This is the first report of sinus node dysfunction associated with lacosamide therapy.

引用

页码：e90 / e93

页数：4

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