Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion

被引：12

作者：

Boteon, Yuri ^{[1
,2
]}

Carvalho, Mauricio Alfredo Flores ^{[3
]}

Panconesi, Rebecca ^{[3
]}

Muiesan, Paolo ^{[3
,4
,5
,6
]}

Schlegel, Andrea ^{[3
]}

机构：

[1] Albert Einstein Hosp, Liver Unit, BR-05652900 Sao Paulo, Brazil

[2] Albert Einstein Jewish Inst Educ & Res, BR-05652900 Sao Paulo, Brazil

[3] Univ Florence, Dept Clin & Expt Med, Hepatobiliary Unit, AOU Careggi, I-50134 Florence, Italy

[4] Queen Elizabeth Hosp Birmingham, Liver Unit, Birmingham B15 2TH, W Midlands, England

[5] Univ Hosp Birmingham NHS Fdn Trust, NIHR Birmingham Biomed Res Ctr, Birmingham B15 2TT, W Midlands, England

[6] Univ Birmingham, Birmingham B15 2TT, W Midlands, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 16期

关键词：

ischemia reperfusion injury; mitochondria; hepatocellular carcinoma; cancer recurrence; machine perfusion; ISCHEMIA-REPERFUSION INJURY; HYPOTHERMIC OXYGENATED PERFUSION; HEPATOCELLULAR-CARCINOMA RECURRENCE; STATIC COLD-STORAGE; REGULATORY T-CELLS; HEPATIC ISCHEMIA; IMMUNE-RESPONSE; REACTIVE OXYGEN; COMPLEX II; DONATION;

D O I：

10.3390/ijms21165791

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumour recurrence is currently a hot topic in liver transplantation. The basic mechanisms are increasingly discussed, and, for example, recurrence of hepatocellular carcinoma is often described in pre-injured donor livers, which frequently suffer from significant ischemia/reperfusion injury. This review article highlights the underlying mechanisms and describes the specific tissue milieu required to promote tumour recurrence after liver transplantation. We summarise the current literature in this field and show risk factors that contribute to a pro-tumour-recurrent environment. Finally, the potential role of new machine perfusion technology is discussed, including the most recent data, which demonstrate a protective effect of hypothermic oxygenated perfusion before liver transplantation.

引用

页码：1 / 20

页数：20

共 123 条

[1] Redirection of tumor metastasis by expression of E-selectin in vivo
Biancone, L
Araki, M
Araki, K
Vassalli, P
Stamenkovic, I
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (02) : 581 - 587
[2] Predicting Mortality in Patients Developing Recurrent Hepatocellular Carcinoma After Liver Transplantation Impact of Treatment Modality and Recurrence Characteristics
Bodzin, Adam S.
Lunsford, Keri E.
Markovic, Daniela
Harlander-Locke, Michael P.
Busuttil, Ronald W.
Agopian, Vatche G.
[J]. ANNALS OF SURGERY, 2017, 266 (01) : 118 - 125
[3] Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery
Boteon, Yuri L.
Attard, Joseph
Boteon, Amanda P. C. S.
Wallace, Lorraine
Reynolds, Gary
Hubscher, Stefan
Mirza, Darius F.
Mergental, Hynek
Bhogal, Ricky H.
Afford, Simon C.
[J]. LIVER TRANSPLANTATION, 2019, 25 (07) : 1007 - 1022
[4] Boteon Yuri L, 2019, World J Transplant, V9, P14, DOI 10.5500/wjt.v9.i1.14
[5] Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers
Boteon, Yuri L.
Laing, Richard W.
Schlegel, Andrea
Wallace, Lorraine
Smith, Amanda
Attard, Joseph
Bhogal, Ricky H.
Neil, Desley A. H.
Hubscher, Stefan
Perera, M. Thamara P. R.
Mirza, Darius F.
Afford, Simon C.
Mergental, Hynek
[J]. LIVER TRANSPLANTATION, 2018, 24 (12) : 1699 - 1715
[6] Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts
Boteon Y.L.
Afford S.C.
Mergental H.
[J]. Current Transplantation Reports, 2018, 5 (2) : 113 - 120
[7] Brodt P, 1997, INT J CANCER, V71, P612, DOI 10.1002/(SICI)1097-0215(19970516)71:4<612::AID-IJC17>3.0.CO
[8] 2-D
[9] The role of cytokines in hepatocellular carcinoma
Budhu, Anuradha
Wang, Xin Wei
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (06) : 1197 - 1213
[10] Butler A.J., 2020, J HEPATOL, V70, P658

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