Preventing Tumour Recurrence after Liver Transplantation: The Role of Machine Perfusion

被引：15
作者：
Boteon, Yuri [1 ,2 ]
Carvalho, Mauricio Alfredo Flores [3 ]
Panconesi, Rebecca [3 ]
Muiesan, Paolo [3 ,4 ,5 ,6 ]
Schlegel, Andrea [3 ]
机构：
[1] Albert Einstein Hosp, Liver Unit, BR-05652900 Sao Paulo, Brazil
[2] Albert Einstein Jewish Inst Educ & Res, BR-05652900 Sao Paulo, Brazil
[3] Univ Florence, Dept Clin & Expt Med, Hepatobiliary Unit, AOU Careggi, I-50134 Florence, Italy
[4] Queen Elizabeth Hosp Birmingham, Liver Unit, Birmingham B15 2TH, W Midlands, England
[5] Univ Hosp Birmingham NHS Fdn Trust, NIHR Birmingham Biomed Res Ctr, Birmingham B15 2TT, W Midlands, England
[6] Univ Birmingham, Birmingham B15 2TT, W Midlands, England
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 16期
关键词：
ischemia reperfusion injury; mitochondria; hepatocellular carcinoma; cancer recurrence; machine perfusion; ISCHEMIA-REPERFUSION INJURY; HYPOTHERMIC OXYGENATED PERFUSION; HEPATOCELLULAR-CARCINOMA RECURRENCE; STATIC COLD-STORAGE; REGULATORY T-CELLS; HEPATIC ISCHEMIA; IMMUNE-RESPONSE; REACTIVE OXYGEN; COMPLEX II; DONATION;
D O I：
10.3390/ijms21165791
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour recurrence is currently a hot topic in liver transplantation. The basic mechanisms are increasingly discussed, and, for example, recurrence of hepatocellular carcinoma is often described in pre-injured donor livers, which frequently suffer from significant ischemia/reperfusion injury. This review article highlights the underlying mechanisms and describes the specific tissue milieu required to promote tumour recurrence after liver transplantation. We summarise the current literature in this field and show risk factors that contribute to a pro-tumour-recurrent environment. Finally, the potential role of new machine perfusion technology is discussed, including the most recent data, which demonstrate a protective effect of hypothermic oxygenated perfusion before liver transplantation.
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页码：1 / 20
页数：20
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