The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder

被引：35

作者：

Herscu, Paul ^{[1
,2
]}

Handen, Benjamin L. ^{[3
]}

Arnold, L. Eugene ^{[4
]}

Snape, Michael F. ^{[2
,5
]}

Bregman, Joel D. ^{[6
,7
]}

Ginsberg, Lawrence ^{[8
]}

Hendren, Robert ^{[9
,10
]}

Kolevzon, Alexander ^{[11
]}

Melmed, Raun ^{[12
]}

Mintz, Mark ^{[13
,14
]}

Minshew, Nancy ^{[15
]}

Sikich, Linmarie ^{[16
,17
]}

Attalla, Ashraf ^{[18
]}

King, Brian ^{[19
,20
]}

Owley, Thomas ^{[21
]}

Childress, Ann ^{[22
]}

Chugani, Harry ^{[23
,24
]}

Frazier, Jean ^{[25
,26
]}

Cartwright, Charles ^{[27
]}

Murphy, Tanya ^{[28
,29
]}

机构：

[1] Herscu Lab & Consulting LLC, 356 Middle St, Amherst, MA USA

[2] Neuropharm PLC, London, England

[3] Univ Pittsburgh, Sch Med, 1011 Bingham St, Pittsburgh, PA 15203 USA

[4] Ohio State Univ, Nisonger Ctr UCEDD, McCampbell Hall,1581 Dodd Dr, Columbus, OH USA

[5] AMO Pharma Ltd, Throwsters St, Wonersh GU5 0PF, England

[6] United Community & Family Serv Healthcare, Ctr Autism & Neurodev Disorders, 47 Town St, Norwich, CT 06360 USA

[7] North Shore Long Isl Jewish Hlth Syst, New Hyde Pk, NY USA

[8] Red Oak Psychiat Associates, 15115 Red Oak Dr 109, Houston, TX USA

[9] Univ Calif San Francisco, 401 Parnassus Ave,Box 0984, San Francisco, CA 94143 USA

[10] Univ Calif Davis, Sacramento, CA 95817 USA

[11] Mt Sinai Sch Med, Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, Dept Psychiat, One Gustave L Levy Pl,Box 1230, New York, NY USA

[12] Southwest Autism Res & Resource Ctr, 300 N 18th St, Phoenix, AZ USA

[13] Ctr Neurol & Neurodev Hlth, 2050 Voorhees Town Ctr, Voorhees, NJ USA

[14] Clin Res Ctr New Jersey, 2050 Voorhees Town Ctr, Voorhees, NJ USA

[15] Univ Pittsburgh, Sch Med, 3811 OHara St, Pittsburgh, PA USA

[16] Duke Univ, Duke Ctr Autism & Brain Dev, Med Sch, 2608 Erwin Rd,Suite 300, Durham, NC USA

[17] Univ N Carolina, Chapel Hill, NC 27515 USA

[18] Inst Behav Med, 696 Concord Rd SE, Smyrna, GA USA

[19] Univ Calif San Francisco, UCSF Weill Inst Neurosci, 401 Parnassus Ave,Suite LP 358, San Francisco, CA 94143 USA

[20] Univ Washington, Seattle, WA 98195 USA

[21] Univ Illinois, Coll Med, 1835 W Polk St, Chicago, IL USA

[22] Ctr Psychiat & Behav Med Inc, 7351 Prairie Falcon Rd,Suite 160, Las Vegas, NV 89128 USA

[23] NYU, Langone Comprehens Epilepsy Ctr, 223 East 34th St, New York, NY USA

[24] Childrens Hosp Michigan, Detroit, MI 48201 USA

[25] Univ Massachusetts, Med Ctr, 55 Lake Ave North, Worcester, MA 01655 USA

[26] Cambridge Hlth Alliance, Cambridge, MA USA

[27] Spectrum Hlth Associates, 210 Bellevue Ave, Montclair, NJ USA

[28] Univ S Florida, Rothman Ctr Pediat Neuropsychiat, 880 6th St South, St Petersburg, FL USA

[29] Univ Florida, Gainesville, FL USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2020年 / 50卷 / 09期

关键词：

Autism spectrum disorder; Repetitive behavior; Selective seretonin reuptake inhibitor; SEROTONIN TRANSPORTER OCCUPANCY; OBSESSIVE-COMPULSIVE DISORDER; PLACEBO-CONTROLLED TRIAL; SELF-STIMULATION; DOUBLE-BLIND; REUPTAKE INHIBITORS; SPECTRUM DISORDERS; CROSSOVER TRIAL; YOUNG-PEOPLE; ADULTS;

D O I：

10.1007/s10803-019-04120-y

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that reduces obsessive-compulsive symptoms. There is limited evidence supporting its efficacy for repetitive behaviors (RRBs) in autistic spectrum disorder (ASD). We conducted a randomized controlled trial (RCT) of fluoxetine in 158 individuals with ASD (5-17 years). Following 14 treatment weeks (mean dose 11.8 mg/day), no significant differences were noted on the Children's Yale-Brown Obsessive Compulsive Scale; the proportion of responders was similar (fluoxetine: 36%; placebo: 41%). There were similar rates of AEs (e.g., insomnia, diarrhea, vomiting); high rates of activation were reported in both groups (fluoxetine: 42%; placebo: 45%). Overly cautious dosing/duration may have prevented attainment of a therapeutic level. Results are consistent with other SSRI RCTs treating RRBs in ASD. Trial Registration: clinicaltrials.gov Identifier: NCT00515320.

引用

页码：3233 / 3244

页数：12

共 53 条

[1]

[Anonymous], 2000, DIAGN STAT MAN MENT, P4

[2]

[Anonymous], 2013, Memorandum, Transitioning to the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders

[3]

[Anonymous], 2012, AUTISM DIAGNOSTIC OB

[4]

Asperger H., 1991, AUTISM ASPERGER SYND, P37, DOI DOI 10.1017/CBO9780511526770.002

[5] Varieties of repetitive behavior in autism: Comparisons to mental retardation [J].

Bodfish, JW ;

Symons, FJ ;

Parker, DE ;

Lewis, MH .

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2000, 30 (03) :237-243

[6] The caregiver strain questionnaire: Measuring the impact on the family of living with a child with serious emotional disturbance [J].

Brannan, AM ;

Heflinger, CA ;

Bickman, L .

JOURNAL OF EMOTIONAL AND BEHAVIORAL DISORDERS, 1997, 5 (04) :212-222

[7]

Chugani DC, 1999, ANN NEUROL, V45, P287, DOI 10.1002/1531-8249(199903)45:3<287::AID-ANA3>3.0.CO

[8]

2-9

[9] FLUOXETINE TREATMENT OF CHILDREN AND ADULTS WITH AUTISTIC DISORDER AND MENTAL-RETARDATION [J].

COOK, EH ;

ROWLETT, R ;

JASELSKIS, C ;

LEVENTHAL, BL .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1992, 31 (04) :739-745

[10]

DeLong GR, 2002, DEV MED CHILD NEUROL, V44, P652

← 1 2 3 4 5 6 →