Sequence analysis of the whole genome of a recombinant Marek's disease virus strain, GX0101, with a reticuloendotheliosis virus LTR insert

被引：11
作者：
Su, Shuai [1 ]
Cui, Ning [1 ]
Sun, Aijun [2 ]
Li, Yanpeng [3 ]
Ding, Jiabo [4 ]
Chen, Zimeng [1 ]
Zhao, Peng [1 ]
Cui, Zhizhong [1 ]
机构：
[1] Shandong Agr Univ, Coll Vet Med, Tai An 271018, Shandong, Peoples R China
[2] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Pathobiol, College Stn, TX 77843 USA
[3] Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China
[4] China Inst Vet Drug Control, Beijing 100081, Peoples R China
来源：
ARCHIVES OF VIROLOGY | 2013年 / 158卷 / 09期
基金：
中国国家自然科学基金;
关键词：
LONG TERMINAL REPEAT; FIELD STRAIN; RETROVIRUS INSERTION; HERPESVIRUS; CLONE;
D O I：
10.1007/s00705-013-1671-1
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Marek's disease virus Chinese strain GX0101, isolated in 2001, is the first reported recombinant gallid herpesvirus type 2 (GaHV-2) field strain with one reticuloendotheliosis virus (REV) long terminal repeat (LTR) insert. We constructed an infectious bacterial artificial chromosome (BAC) clone of GX0101, which showed characteristics very similar to those of the parental virus in replication and pathogenicity. Using the GX0101 BAC clone, the complete genome of GX0101 was sequenced and analyzed. The length of the GX0101 genome is 178,101 bp, and it contains only one REV-LTR insert at a site 267 bp upstream of the sorf2 gene.
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页码：2007 / 2014
页数：8
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