The Sec-dependent pathway

被引:77
作者
Beckwith, Jon [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02215 USA
关键词
SRP; SecYEG; Post-translational secretion; Co-translational secretion; Gene fusions; COLI OUTER-MEMBRANE; IMMUNOGLOBULIN LIGHT-CHAINS; SIGNAL-SEQUENCE MUTATIONS; MALTOSE-BINDING-PROTEIN; ESCHERICHIA-COLI; EXPORTED PROTEINS; COAT PROTEIN; ENDOPLASMIC-RETICULUM; PREPROTEIN TRANSLOCASE; MICROSOMAL-MEMBRANES;
D O I
10.1016/j.resmic.2013.03.007
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The Sec pathway for export of proteins across the cytoplasmic membrane to the bacterial periplasm and outer membrane was the first secretion pathway to be discovered in bacteria. A combination of bacterial genetics, development of an in vitro membrane vesicle system and the concurrent elaboration of the signal hypothesis from studies on eukaryotes led to the identification and characterization of two pathways leading to protein export through the SecYEG cytoplasmic membrane translocon. The Sec pathway is also required for assembly of proteins into the cytoplasmic membrane. Since the membrane translocon for Sec pathways is conserved across the three domains of life, the history of research progress in eukaryotes and bacteria was facilitated by the close interaction between those studying both classes of organisms. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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页码:497 / 504
页数:8
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