Lanthanide-Based Optical Probes of Biological Systems

被引:75
作者
Cho, Ukrae [1 ,4 ]
Chen, James K. [1 ,2 ,3 ]
机构
[1] Stanford Univ, Dept Chem & Syst Biol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
[4] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA
关键词
RESONANCE ENERGY-TRANSFER; UP-CONVERSION NANOPARTICLES; PROTEIN-PROTEIN INTERACTIONS; LUMINESCENCE FLOW-CYTOMETRY; DOPED QUANTUM DOTS; BINDING-TAGS; IMAGING MICROSCOPY; METAL-COMPLEXES; IN-VIVO; CONFORMATIONAL-CHANGES;
D O I
10.1016/j.chembiol.2020.07.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The unique photophysical properties of lanthanides, such as europium, terbium, and ytterbium, make them versatile molecular probes of biological systems. In particular, their long-lived photoluminescence, narrow bandwidth emissions, and large Stokes shifts enable experiments that are infeasible with organic fluorophores and fluorescent proteins. The ability of these metal ions to undergo luminescence resonance energy transfer, and photon upconversion further expands the capabilities of lanthanide probes. In this review, we describe recent advances in the design of lanthanide luminophores and their application in biological research. We also summarize the latest detection systems that have been developed to fully exploit the optical properties of lanthanide luminophores. We conclude with a discussion of remaining challenges and new frontiers in lanthanide technologies. The unprecedented levels of sensitivity and multiplexing afforded by rare-earth elements illustrate how chemistry can enable new approaches in biology.
引用
收藏
页码:921 / 936
页数:16
相关论文
共 181 条
[1]   Fluorescent Protein Based FRET Pairs with Improved Dynamic Range for Fluorescence Lifetime Measurements [J].
Abraham, Bobin George ;
Sarkisyan, Karen S. ;
Mishin, Alexander S. ;
Santala, Ville ;
Tkachenko, Nikolai V. ;
Karp, Matti .
PLOS ONE, 2015, 10 (08)
[2]   Multicolor Electron Microscopy for Simultaneous Visualization of Multiple Molecular Species [J].
Adams, Stephen R. ;
Mackey, Mason R. ;
Ramachandra, Ranjan ;
Lemieux, Sakina F. Palida ;
Steinbach, Paul ;
Bushong, Eric A. ;
Butko, Margaret T. ;
Giepmans, Ben N. G. ;
Ellisman, Mark H. ;
Tsien, Roger Y. .
CELL CHEMICAL BIOLOGY, 2016, 23 (11) :1417-1427
[3]   Time-gated FRET nanoassemblies for rapid and sensitive intra- and extracellular fluorescence imaging [J].
Afsari, Hamid Samareh ;
Dos Santos, Marcelina Cardoso ;
Linden, Stina ;
Chen, Ting ;
Qiu, Xue ;
Henegouwen, Paul M. P. van Bergen En ;
Jennings, Travis L. ;
Susumu, Kimihiro ;
Medintz, Igor L. ;
Hildebrandt, Niko ;
Miller, Lawrence W. .
SCIENCE ADVANCES, 2016, 2 (06)
[4]   FRET as a biomolecular research tool-understanding its potential while avoiding pitfalls [J].
Algar, W. Russ ;
Hildebrandt, Niko ;
Vogel, Steven S. ;
Medintz, Igor L. .
NATURE METHODS, 2019, 16 (09) :815-829
[5]   Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine [J].
Ali, M. Monsur ;
Li, Feng ;
Zhang, Zhiqing ;
Zhang, Kaixiang ;
Kang, Dong-Ku ;
Ankrum, James A. ;
Le, X. Chris ;
Zhao, Weian .
CHEMICAL SOCIETY REVIEWS, 2014, 43 (10) :3324-3341
[6]   Multiplexed ion beam imaging of human breast tumors [J].
Angelo, Michael ;
Bendall, Sean C. ;
Finck, Rachel ;
Hale, Matthew B. ;
Hitzman, Chuck ;
Borowsky, Alexander D. ;
Levenson, Richard M. ;
Lowe, John B. ;
Liu, Scot D. ;
Zhao, Shuchun ;
Natkunam, Yasodha ;
Nolan, Garry P. .
NATURE MEDICINE, 2014, 20 (04) :436-+
[7]  
[Anonymous], 2011, Bioanal. Rev
[8]   Design of luminescent lanthanide complexes: From molecules to highly efficient photo-emitting materials [J].
Armelao, L. ;
Quici, S. ;
Barigelletti, F. ;
Accorsi, G. ;
Bottaro, G. ;
Cavazzini, M. ;
Tondello, E. .
COORDINATION CHEMISTRY REVIEWS, 2010, 254 (5-6) :487-505
[9]   Lanthanide complexes for luminescence-based sensing of low molecular weight analytes [J].
Aulsebrook, Margaret L. ;
Graham, Bim ;
Grace, Michael R. ;
Tuck, Kellie L. .
COORDINATION CHEMISTRY REVIEWS, 2018, 375 :191-220
[10]  
B_unzli J.-C.G., 2016, HDB PHYS CHEM RARE E, V50