Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease

被引：20
作者：
Giachino, Claudia [1 ]
Orlando, Luca [1 ]
Turinetto, Valentina [1 ]
机构：
[1] Univ Turin, Dept Clin & Biol Sci, I-10043 Turin, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 02期
关键词：
embryonic stem cells; genotoxic stress; DNA repair; aging; tumor; NUCLEOTIDE EXCISION-REPAIR; HOMOLOGOUS RECOMBINATION; SOMATIC-CELLS; DNA-DAMAGE; MOLECULAR-MECHANISMS; SELF-RENEWAL; LIFE-SPAN; CANCER; MISMATCH; EXPRESSION;
D O I：
10.3390/ijms14022617
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.
引用
收藏
页码：2617 / 2636
页数：20
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