Small DNA circles as probes of DNA topology

被引：21

作者：

Bates, Andrew D. ^{[1
]}

Noy, Agnes ^{[2
]}

Piperakis, Michael M. ^{[3
]}

Harris, Sarah A. ^{[2
]}

Maxwell, Anthony ^{[3
]}

机构：

[1] Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England

[2] Univ Leeds, Sch Phys & Astron, Leeds LS2 9JT, W Yorkshire, England

[3] John Innes Ctr Plant Sci Res, Dept Biol Chem, Norwich NR4 7UH, Norfolk, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

atomistic simulation; DNA circle; minicircle; supercoiling; topoisomerase; RING-CLOSURE PROBABILITIES; AMBER FORCE-FIELD; CHROMATIN RECONSTITUTION; CIRCULAR DNAS; NUCLEIC-ACIDS; WRITHE; TWIST; SIMULATIONS; CYCLIZATION; FLEXIBILITY;

D O I：

10.1042/BST20120320

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA. In the present article, we review the occurrence and synthesis of small DNA circles, and examine their utility in studying the properties of DNA and DNA-protein interactions. In particular, we highlight the analysis of small circles using atomistic simulations.

引用

页码：565 / 570

页数：6

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