Light-induced molecular rotation triggers on-demand release from liposomes

被引：14
|
作者：
Ribovski, Lais [1 ,2 ]
Zhou, Qihui [3 ]
Chen, Jiawen [4 ]
Feringa, Ben L. [4 ]
van Rijn, Patrick [1 ]
Zuhorn, Inge S. [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands
[2] Univ Sao Paulo, Phys Inst Sao Carlos, Nanomed & Nanotoxicol Grp, CP 369, BR-13560970 Sao Carlos, SP, Brazil
[3] Qingdao Univ, Affiliated Hosp, Inst Translat Med, Dept Periodontol, Qingdao 266021, Peoples R China
[4] Univ Groningen, Ctr Syst Chem, Stratingh Inst Chem, Nijenborgh 4, NL-9747 AG Groningen, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 62期
基金：
欧洲研究理事会;
关键词：
NANOMEDICINE; DELIVERY; MOTORS;
D O I：
10.1039/d0cc02499f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Controllable molecular release from delivery vehicles is essential to successfully reduce drug toxicity and improve therapeutic efficacy. Light-powered hydrophobic molecular motors were therefore incorporated in liposomes to use molecular rotation to facilitate on-demand release. The extent of the release was precisely controlled by irradiation times, providing a simple yet sophisticated responsive molecular nanocarrier.
引用
收藏
页码：8774 / 8777
页数：4
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