Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

被引：863

作者：

Kunnumakkara, Ajaikumar B. ^{[1
]}

Anand, Preetha ^{[1
]}

Aggarwal, Bharat B. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Cytokine Res Lab, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2008年 / 269卷 / 02期

关键词：

Curcumin; Molecular targets; Cancer; Inflammation;

D O I：

10.1016/j.canlet.2008.03.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because most cancers are caused by dysregulation of as many as 500 different genes, agents that target multiple gene products are needed for prevention and treatment of cancer. Curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their expression and activity. These include inflammatory cytokines and enzymes, transcription factors, and gene products linked with cell survival, proliferation, invasion, and angiogenesis. Curcumin has been found to inhibit the proliferation of various tumor cells in culture, prevents carcinogen-induced cancers in rodents, and inhibits the growth of human tumors in xenotransplant or orthotransplant animal models either alone or in combination with chemotherapeutic agents or radiation. Several phase I and phase II clinical trials indicate that curcumin is quite safe and may exhibit therapeutic efficacy. These aspects of curcumin arc discussed further in detail in this review. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：199 / 225

页数：27

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