Genetic Instability, DNA Damage and Atherosclerosis

被引:14
作者
Andreassi, Maria Grazia [1 ]
Botto, Nicoletta [1 ]
机构
[1] G Pasquinucci Hosp, CNR, Inst Clin Physiol, Lab Cellular Biol, I-54100 Massa, Italy
关键词
Atherosclerosis; Cancer; Mutation; DNA damage; Chemopreventive therapeutic agents;
D O I
10.4161/cc.2.3.403
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We review the role of somatic mutations and genetic instability in the pathogenesis of atherosclerosis, suggesting novel therapeutic approaches.
引用
收藏
页码:224 / 227
页数:4
相关论文
共 51 条
[1]  
Andreassi MG, 2000, ENVIRON MOL MUTAGEN, V35, P265, DOI 10.1002/1098-2280(2000)35:4<265::AID-EM1>3.0.CO
[2]  
2-M
[3]   Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease [J].
Andreassi, MG ;
Botto, N ;
Cocci, F ;
Battaglia, D ;
Antonioli, E ;
Masetti, S ;
Manfredi, S ;
Colombo, MG ;
Biagini, A ;
Clerico, A .
HUMAN GENETICS, 2003, 112 (02) :171-177
[4]   Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage [J].
Andreassi, MG .
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2003, 543 (01) :67-86
[5]   Deoxyribonucleic acid damage in human lymphocytes after percutaneous transluminal coronary angioplasty [J].
Andreassi, MG ;
Botto, N ;
Rizza, A ;
Colombo, MG ;
Palmieri, C ;
Berti, S ;
Manfredi, S ;
Masetti, S ;
Clerico, A ;
Biagini, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (05) :862-868
[6]   Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells - Potential role of p53 in regulation of vascular smooth muscle cell growth [J].
Aoki, M ;
Morishita, R ;
Matsushita, H ;
Hayashi, S ;
Nakagami, H ;
Yamamoto, K ;
Moriguchi, A ;
Kaneda, Y ;
Higaki, J ;
Ogihara, T .
HYPERTENSION, 1999, 34 (02) :192-200
[7]   Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement [J].
Bailey, LB ;
Gregory, JF .
JOURNAL OF NUTRITION, 1999, 129 (05) :919-922
[8]   Pathophysiological effects of radiation on atherosclerosis development and progression, and the incidence of cardiovascular complications [J].
Basavaraju, SR ;
Easterly, CE .
MEDICAL PHYSICS, 2002, 29 (10) :2391-2403
[9]   Atherosclerotic risks from chemicals: Part I. Toxicological observations and mechanisms of atherosclerosis [J].
Basavaraju, SR ;
Jones, TD .
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1998, 35 (01) :152-164
[10]   EVIDENCE FOR A MONOCLONAL ORIGIN OF HUMAN ATHEROSCLEROTIC PLAQUES [J].
BENDITT, EP ;
BENDITT, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (06) :1753-1756