Transcranial ultrasound-improved thrombolysis: Diagnostic vs. therapeutic ultrasound

被引：101
作者：
Behrens, S
Spengos, K
Daffertshofer, M
Schroeck, H
Dempfle, CE
Hennerici, M [1 ]
机构：
[1] Univ Heidelberg, Univ Klinikum Mannheim, Dept Neurol, D-68135 Mannheim, Germany
[2] Univ Heidelberg, Univ Klinikum Mannheim, Dept Internal Med 1, D-68135 Mannheim, Germany
[3] Univ Heidelberg, Inst Physiol, D-6800 Mannheim, Germany
来源：
ULTRASOUND IN MEDICINE AND BIOLOGY | 2001年 / 27卷 / 12期
关键词：
cerebral revascularization; ultrasonics; thrombolysis; blood-brain barrier;
D O I：
10.1016/S0301-5629(01)00481-1
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US. In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm(2)) and in comparison to 1-MHz diagnostic US (0.5 W/cm(2)). Recanalization time was significantly (p < 0.01) shorter in the 185-kHz (14.1 min) and 1-MHz (17.1 min) US rt-PA treatment group compared to rt-PA treatment alone (29.3 min.). Flow rate was significantly higher (P < 0.025) and increased faster in the combined treatment group with rt-PA + 185-kHz US compared to rt-PA + 1-MHz US. We investigated the blood-brain barrier in rats after 90-min exposure time of the brain with 185-kHz US, but no damage was observed. Results suggest efficacy and safety of the 185-kHz transducer, which is superior to diagnostic US. Such a novel US probe may be able to optimize thrombolytic stroke treatment. (E-mail: hennerici@neuro.ma.uni-heidelberg.de) (C) 2002 World Federation for Ultrasound in Medicine Biology.
引用
收藏
页码：1683 / 1689
页数：7
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