Application of Ozone Therapy in Patients with Knee Osteoarthritis

被引：34

作者：

Luis Calunga, Jose ^{[1
]}

Menendez, Silvia ^{[1
]}

Leon, Rodolfo ^{[2
]}

Chang, Soulien ^{[3
]}

Guanche, Dailen ^{[1
]}

Balbin, Alberto ^{[4
]}

Zayas, Jose ^{[4
]}

Garcia, Pedro ^{[4
]}

机构：

[1] Natl Ctr Sci Res, Ozone Res Ctr, Ozone Int Clin, Havana, Cuba

[2] AA Aballi Pediat Teaching Hosp, Havana, Cuba

[3] Univ Havana, Pharmaceut & Food Inst, Havana, Cuba

[4] Dr Fructuoso Rodriguez Orthoped Hosp, Havana, Cuba

来源：

OZONE-SCIENCE & ENGINEERING | 2012年 / 34卷 / 06期

关键词：

Ozone Therapy; Osteoarthritis; Synovial Fluids; Pain; Oxidative Stress; LIPID-PEROXIDATION; SUPEROXIDE-DISMUTASE; ARTICULAR-CARTILAGE; SYNOVIAL-FLUID; ANTIOXIDANT ENZYMES; OXIDATIVE STRESS; RAT MODEL; VITAMIN-E; PROTECTION; DAMAGE;

D O I：

10.1080/01919512.2012.719120

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Osteoarthritis is a common degenerative joint disease. Taking into account the ozone (O3) effects in cellular redox balance and upon biomarkers of inflammation, the aim of this study was to evaluate the action of ozone therapy in oxidative stress parameters in synovial fluid of patients suffering of knee osteoarthritis and their clinical evolution. In 42 patients, O3 was administered rectally and by intra-articular applications. Synovial fluid was extracted for the measurement of parameters associated with oxidative stress. Also, evaluation of the joint capacity, pain, and ultrasound imaging were performed. Combined ozone therapy produced an intra-articular redox balance and a significant reduction of pain.

引用

页码：469 / 475

页数：7

共 48 条

[1] Reactive oxygen species and superoxide dismutases: Role in joint diseases [J].

Afonso, Valery ;

Champy, Rornuald ;

Mitrovic, Dragoslav ;

Collin, Pascal ;

Lomri, Abderrahim .

JOINT BONE SPINE, 2007, 74 (04) :324-329

[2] Similar protective effect of ischaemic and ozone oxidative preconditionings in liver ischaemia/reperfusion injury [J].

Ajamieh, H ;

Merino, N ;

Candelario-Jalil, E ;

Menéndez, S ;

Martinez-Sanchez, G ;

Re, L ;

Giuliani, A ;

Leon, OS .

PHARMACOLOGICAL RESEARCH, 2002, 45 (04) :333-339

[3] Role of protein synthesis in the protection conferred by ozone-oxidative-preconditioning in hepatic ischaemia/reperfusion [J].

Ajamieh, HH ;

Berlanga, J ;

Merino, N ;

Sánchez, GM ;

Carmona, AM ;

Cepero, SM ;

Giuliani, A ;

Re, L ;

León, OS .

TRANSPLANT INTERNATIONAL, 2005, 18 (05) :604-612

[4] Ischemic and ozone oxidative preconditioning in the protection against hepatic ischemic-reperfusion injury [J].

Ajamieh, HH ;

Menéndez, S ;

Merino, N ;

Martínez-Sánchez, G ;

Re, L ;

León, OS .

OZONE-SCIENCE & ENGINEERING, 2003, 25 (03) :241-250

[5] Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion [J].

Ajamieh, HH ;

Menéndez, S ;

Martínez-Sánchez, G ;

Candelario-Jalil, E ;

Re, L ;

Giuliani, A ;

Fernández, OSL .

LIVER INTERNATIONAL, 2004, 24 (01) :55-62

[6]

Al-Dalain SM, 2001, PHARMACOL RES, V44, P391

[7] Effect of exercise on bone and articular cartilage in heterozygous manganese superoxide dismutase (SOD2) deficient mice [J].

Baur, Alexander ;

Henkel, Jan ;

Bloch, Wilhelm ;

Treiber, Nicolai ;

Scharffetter-Kochanek, Karin ;

Brueggemann, Gert-Peter ;

Niehoff, Anja .

FREE RADICAL RESEARCH, 2011, 45 (05) :550-558

[8]

Bocci V., 2002, Oxygen-ozone therapy: a critical evaluation, P121

[9]

Bocci VA, 2006, ARCH MED RES, V37, P425, DOI 10.1016/j.arcmed.2005.08.006

[10]

Boehringer Mannheim, 1987, BIOCH INFORM ENZYMES, P15

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