共 53 条
Host defense pathways against fungi: the basis for vaccines and immunotherapy
被引:17
作者:

Carvalho, Agostinho
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机构:
Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy
Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
ICVS 3Bs PT Govt Associate Lab, Braga, Portugal Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

Cunha, Cristina
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Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

Iannitti, Rossana G.
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Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

Casagrande, Andrea
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机构:
Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy
Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

Bistoni, Francesco
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机构:
Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

Aversa, Franco
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机构:
Univ Parma, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy

Romani, Luigina
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机构:
Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy
机构:
[1] Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy
[2] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
[3] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal
[4] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
[5] Univ Parma, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy
关键词:
fungi;
immune responses;
vaccines;
immunotherapy;
vaccinomics;
D O I:
10.3389/fmicb.2012.00176
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Fungal vaccines have long been a goal in the fields of immunology and microbiology to counter the high mortality and morbidity rates owing to fungal diseases, particularly in immunocompromised patients. However, the design of effective vaccination formulations for durable protection to the different fungi has lagged behind due to the important differences among fungi and their biology and our limited understanding of the complex host pathogen interactions and immune responses. Overcoming these challenges is expected to contribute to improved vaccination strategies aimed at personalized efficacy across distinct target patient populations. This likely requires the integration of multifaceted approaches encompassing advanced immunology, systems biology, immunogenetics, and bioinformatics in the fields of fungal and host biology and their reciprocal interactions.
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[21]
Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum
[J].
Deepe, GS
;
Gibbons, RS
.
INFECTION AND IMMUNITY,
2002, 70 (07)
:3759-3767

Deepe, GS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Coll Med, Dept Med, Div Infect Dis, Cincinnati, OH 45267 USA

Gibbons, RS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Cincinnati, Coll Med, Dept Med, Div Infect Dis, Cincinnati, OH 45267 USA
[22]
CD4+ T Cells Mediate the Protective Effect of the Recombinant Asp f3-Based Anti-Aspergillosis Vaccine
[J].
Diaz-Arevalo, Diana
;
Bagramyan, Karine
;
Hong, Teresa B.
;
Ito, James I.
;
Kalkum, Markus
.
INFECTION AND IMMUNITY,
2011, 79 (06)
:2257-2266

Diaz-Arevalo, Diana
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA

Bagramyan, Karine
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA

Hong, Teresa B.
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA

Ito, James I.
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Div Infect Dis, Duarte, CA 91010 USA City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA

Kalkum, Markus
论文数: 0 引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA City Hope Natl Med Ctr, Beckman Res Inst, Dept Immunol, Duarte, CA 91010 USA
[23]
Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded β-Glucan Particles
[J].
Huang, Haibin
;
Ostroff, Gary R.
;
Lee, Chrono K.
;
Specht, Charles A.
;
Levitz, Stuart M.
.
MBIO,
2010, 1 (03)

Huang, Haibin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Ostroff, Gary R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Lee, Chrono K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Specht, Charles A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Levitz, Stuart M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
[24]
Vaccinations with recombinant variants of Aspergillus fumigatus allergen Asp f 3 protect mice against invasive aspergillosis
[J].
Ito, James I.
;
Lyons, Joseph M.
;
Hong, Teresa B.
;
Tamae, Daniel
;
Liu, Yi-Kuang
;
Wilczynski, Sharon P.
;
Kalkum, Markus
.
INFECTION AND IMMUNITY,
2006, 74 (09)
:5075-5084

Ito, James I.
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA

Lyons, Joseph M.
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA

Hong, Teresa B.
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA

Tamae, Daniel
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA

Liu, Yi-Kuang
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA

Wilczynski, Sharon P.
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA

Kalkum, Markus
论文数: 0 引用数: 0
h-index: 0
机构: City Hope Natl Med Ctr, Div Immunol, Duarte, CA 91010 USA
[25]
The Top Five "Game Changers" in Vaccinology: Toward Rational and Directed Vaccine Development
[J].
Kennedy, Richard B.
;
Poland, Gregory A.
.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY,
2011, 15 (09)
:533-537

Kennedy, Richard B.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Dept Internal Med, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Mayo Vaccine Res Grp, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Program Translat Immunovirol & Biodefense, Rochester, MN 55905 USA Mayo Clin, Coll Med, Dept Internal Med, Rochester, MN 55905 USA

Poland, Gregory A.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Coll Med, Dept Internal Med, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Mayo Vaccine Res Grp, Rochester, MN 55905 USA
Mayo Clin, Coll Med, Program Translat Immunovirol & Biodefense, Rochester, MN 55905 USA Mayo Clin, Coll Med, Dept Internal Med, Rochester, MN 55905 USA
[26]
A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection
[J].
Klugman, KP
;
Madhi, SA
;
Huebner, RE
;
Kohberger, R
;
Mbelle, N
;
Pierce, N
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003, 349 (14)
:1341-1348

Klugman, KP
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30322 USA

Madhi, SA
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30322 USA

Huebner, RE
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30322 USA

Kohberger, R
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30322 USA

Mbelle, N
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30322 USA

Pierce, N
论文数: 0 引用数: 0
h-index: 0
机构: Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30322 USA
[27]
A model vaccine exploiting fungal mannosylation to increase antigen immunogenicity
[J].
Lam, JS
;
Mansour, MK
;
Specht, CA
;
Levitz, SM
.
JOURNAL OF IMMUNOLOGY,
2005, 175 (11)
:7496-7503

Lam, JS
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Med Ctr, Evans Mem Dept Med, Infect Dis Sect, Boston, MA 02118 USA

Mansour, MK
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Med Ctr, Evans Mem Dept Med, Infect Dis Sect, Boston, MA 02118 USA

Specht, CA
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Med Ctr, Evans Mem Dept Med, Infect Dis Sect, Boston, MA 02118 USA

Levitz, SM
论文数: 0 引用数: 0
h-index: 0
机构: Boston Univ, Med Ctr, Evans Mem Dept Med, Infect Dis Sect, Boston, MA 02118 USA
[28]
Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research
[J].
Levitz, Stuart M.
;
Golenbock, Douglas T.
.
CELL,
2012, 148 (06)
:1284-1292

Levitz, Stuart M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

Golenbock, Douglas T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
[29]
Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses
[J].
Littman, Dan R.
;
Pamer, Eric G.
.
CELL HOST & MICROBE,
2011, 10 (04)
:311-323

Littman, Dan R.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med,Mol Pathogenesis Program, New York, NY 10016 USA
NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med,Howard Hughes Med Inst, New York, NY 10016 USA NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med,Mol Pathogenesis Program, New York, NY 10016 USA

Pamer, Eric G.
论文数: 0 引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Program Immunol, Lucille Castori Ctr Microbes Inflammat & Canc, Sloan Kettering Inst, New York, NY 10065 USA
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, Dept Med, New York, NY 10065 USA NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med,Mol Pathogenesis Program, New York, NY 10016 USA
[30]
TLR2 Is a Negative Regulator of Th17 Cells and Tissue Pathology in a Pulmonary Model of Fungal Infection
[J].
Loures, Flavio V.
;
Pina, Adriana
;
Felonato, Maira
;
Calich, Vera L. G.
.
JOURNAL OF IMMUNOLOGY,
2009, 183 (02)
:1279-1290

Loures, Flavio V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil

Pina, Adriana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil

Felonato, Maira
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil

Calich, Vera L. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 Sao Paulo, Brazil