Host defense pathways against fungi: the basis for vaccines and immunotherapy

被引:17
作者
Carvalho, Agostinho [1 ,2 ,3 ]
Cunha, Cristina [1 ]
Iannitti, Rossana G. [1 ]
Casagrande, Andrea [1 ,4 ]
Bistoni, Francesco [1 ]
Aversa, Franco [5 ]
Romani, Luigina [1 ]
机构
[1] Univ Perugia, Dept Expt Med & Biochem Sci, I-06122 Perugia, Italy
[2] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
[3] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal
[4] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy
[5] Univ Parma, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy
关键词
fungi; immune responses; vaccines; immunotherapy; vaccinomics;
D O I
10.3389/fmicb.2012.00176
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Fungal vaccines have long been a goal in the fields of immunology and microbiology to counter the high mortality and morbidity rates owing to fungal diseases, particularly in immunocompromised patients. However, the design of effective vaccination formulations for durable protection to the different fungi has lagged behind due to the important differences among fungi and their biology and our limited understanding of the complex host pathogen interactions and immune responses. Overcoming these challenges is expected to contribute to improved vaccination strategies aimed at personalized efficacy across distinct target patient populations. This likely requires the integration of multifaceted approaches encompassing advanced immunology, systems biology, immunogenetics, and bioinformatics in the fields of fungal and host biology and their reciprocal interactions.
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页数:6
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