TBAI-catalyzed synthesis of α-ketoamides via sp3 C-H radical/radical cross-coupling and domino aerobic oxidation

被引：21
|
作者：
Fan, Weizheng [1 ]
Shi, Dongyang [1 ]
Feng, Bainian [1 ]
机构：
[1] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Peoples R China
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 31期
基金：
中国国家自然科学基金;
关键词：
TBAI-catalyzed; alpha-Ketoamides; Radical/radical cross-coupling; Aerobic oxidation; sp(3) C-H bond; KETO AMIDE INHIBITORS; METAL-FREE; METHYL KETONES; ROOM-TEMPERATURE; AMINES; ACCESS; ACETOPHENONES; AMIDATION; N; N-DIMETHYLFORMAMIDE; DERIVATIVES;
D O I：
10.1016/j.tetlet.2015.06.021
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A TBAI-catalyzed one-pot synthesis of cx-ketoamides via sp(3) C-H radical/radical cross-coupling and domino aerobic oxidation was developed. This synthesis is suitable for abroad range of substrates. The control experiments suggested a possible oxidative coupling mechanism. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4638 / 4641
页数：4
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