Emerging role of extracellular vesicles in lung injury and inflammation

被引：63

作者：

Zhang Lanyu ^{[1
,2
]}

Hei Feilong ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiopulm Bypass,State key Lab Cardiovasc D, North Lishi Rd,Beijing 167, Beijing 100037, Peoples R China

[2] Peking Union Med Coll, North Lishi Rd,Beijing 167, Beijing 100037, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 113卷

基金：

中国国家自然科学基金;

关键词：

Lung injury; Inflammation; Extracellular vesicle; Exosome; Microvesicle; Mesenchymal stem cell; OBSTRUCTIVE PULMONARY-DISEASE; MESENCHYMAL STROMAL CELLS; STEM-CELL; MICROPARTICLE LEVELS; MEMBRANE-VESICLES; MESSENGER-RNA; EXOSOMES; MICROVESICLES; MACROPHAGES; MECHANISM;

D O I：

10.1016/j.biopha.2019.108748

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lung injury and inflammation are common characterizes in many pulmonary diseases. Alveolar epithelial cells, macrophages, pulmonary microvascular endothelial cells, and neutrophils, play crucial roles in lung injury and inflammation. They can secrete extracellular vesicles (EVs), involving exosomes, microvesicles, and apoptotic bodies. EVs are considered to be novel cell-cell communication tools, transferring diverse substances such as proteins, nucleic acid and lipids. Recently, the effects of EVs produced by pulmonary structural cells, immunoregulatory cells and stem cells on pulmonary diseases have attracted much attention. We summarized the recent findings of EV-related pathogeneses, therapies and diagnoses for lung injury and inflammation in this review.

引用

页数：9

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