Evidence for hormonal control of heart regenerative capacity during endothermy acquisition

被引：281

作者：

Hirose, Kentaro ^{[1
,2
,3
]}

Payumo, Alexander Y. ^{[1
,2
,3
]}

Cutie, Stephen ^{[1
,2
,3
]}

Hoang, Alison ^{[1
,2
,3
]}

Zhang, Hao ^{[4
]}

Guyot, Romain ^{[5
]}

Lunn, Dominic ^{[1
,2
,3
]}

Bigley, Rachel B. ^{[1
,2
,3
]}

Yu, Hongyao ^{[6
]}

Wang, Jiajia ^{[6
]}

Smith, Megan ^{[7
]}

Gillett, Ellen ^{[8
]}

Muroy, Sandra E. ^{[9
]}

Schmid, Tobias ^{[10
,11
]}

Wilson, Emily ^{[4
]}

Field, Kenneth A. ^{[12
]}

Reeder, DeeAnn M. ^{[12
]}

Maden, Malcom ^{[13
,14
]}

Yartsev, Michael M. ^{[10
,11
]}

Wolfgang, Michael J. ^{[15
]}

Grutzner, Frank ^{[8
]}

Scanlan, Thomas S. ^{[16
]}

Szweda, Luke I. ^{[17
]}

Buffenstein, Rochelle ^{[7
]}

Hu, Guang ^{[6
]}

Flamant, Frederic ^{[5
]}

Olgin, Jeffrey E. ^{[1
,2
,4
]}

Huang, Guo N. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94158 USA

[5] Univ Lyon 1, Dept Internal Med, Inst Genom Fonct Lyon, INRA,CNRS,Ecole Normale Super Lyon, F-69007 Lyon, France

[6] NIEHS, Epigenet & Stem Cell Biol Lab, POB 12233, Res Triangle Pk, NC 27709 USA

[7] Calico Life Sci, 1170 Vet Blvd, San Francisco, CA 94080 USA

[8] Univ Adelaide, Sch Biol Sci, Adelaide, SA 5005, Australia

[9] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94708 USA

[10] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94708 USA

[11] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94708 USA

[12] Bucknell Univ, Dept Biol, Lewisburg, PA 17837 USA

[13] Univ Florida, Dept Biol, Gainesville, FL 32611 USA

[14] Univ Florida, UF Genet Inst, Gainesville, FL 32611 USA

[15] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[16] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA

[17] Univ Texas Southwestern Med Ctr Dallas, Div Cardiol, Dallas, TX 75390 USA

来源：

SCIENCE | 2019年 / 364卷 / 6436期

关键词：

METABOLIC-RATE; ENERGY-EXPENDITURE; ADULT NEWT; TEMPERATURE; ZEBRAFISH; LIZARDS; PROLIFERATION; RECOMBINATION; CONSUMPTION; ACTIVATION;

D O I：

10.1126/science.aar2038

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber's law-the 3/4 -power law scaling of metabolism with bodyweight-and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.

引用

页码：184 / +

页数：57

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