Cross-sectional and longitudinal analysis of an oxidative stress biomarker for spinal and bulbar muscular atrophy

被引：12

作者：

Mano, Tomoo ^{[1
]}

Katsuno, Masahisa ^{[1
]}

Banno, Haruhiko ^{[1
,2
]}

Suzuki, Keisuke ^{[1
]}

Suga, Noriaki ^{[1
]}

Hashizume, Atsushi ^{[1
]}

Tanaka, Fumiaki ^{[1
]}

Sobue, Gen ^{[1
]}

机构：

[1] Nagoya Univ, Dept Neurol, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Inst Adv Res, Nagoya, Aichi 4668550, Japan

来源：

MUSCLE & NERVE | 2012年 / 46卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

androgen receptor; biomarker; motor neuron; oxidative stress; spinal and bulbar muscular atrophy; 6-MINUTE WALK TEST; BULBOSPINAL NEURONOPATHY; DISEASE PATHOGENESIS; PARKINSONS-DISEASE; FRIEDREICHS-ATAXIA; KENNEDY-DISEASE; DNA-DAMAGE; CAG REPEAT; NEURODEGENERATION; PERSPECTIVES;

D O I：

10.1002/mus.23413

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. The aim of this study was to verify whether urinary 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, is a biomarker for SBMA. Methods: We measured the levels of urinary 8-OHdG in 33 genetically confirmed SBMA patients and 32 age-matched controls over a 24-month period at 6-month intervals. Results: Urinary 8-OHdG levels in SBMA patients were significantly elevated compared with those of controls and correlated well with motor function scores. During the follow-up period, urinary 8-OHdG levels increased and correlated with motor function at each time-point. In addition, urinary 8-OHdG levels at baseline were correlated with changes in the 6-minute walk test during 24 months. Conclusions: Urinary 8-OHdG is a biomarker for SBMA, reflecting the severity and possibly predicting the deterioration of motor function. Muscle Nerve, 2012

引用

页码：692 / 697

页数：6

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