A Highly Efficient Friedel-Crafts Reaction of Tertiary α-Hydroxyesters or α-Hydroxyketones to α-Quaternary Esters or Ketones

被引：36

作者：

Chen, Long ^{[1
]}

Zhou, Jian ^{[1
]}

机构：

[1] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Dept Chem, Shanghai 200062, Peoples R China

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2012年 / 7卷 / 11期

关键词：

alcohols; Friedel-Crafts reaction; heterocycles; homogeneous catalysis; ketones; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS; AROMATIC-COMPOUNDS; NUCLEOPHILIC SUBSTITUTIONS; ORGANIC-SYNTHESIS; MICHAEL ADDITION; INDUCE APOPTOSIS; FACILE SYNTHESIS; ATOM EFFICIENCY; MELANOMA-CELLS; ALDOL REACTION;

D O I：

10.1002/asia.201200693

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalytic Friedel-Crafts arylation of α-hydroxyesters or α-hydroxyketones with electron-rich aromatic compounds to furnish α-quaternary esters/ketones has been developed. The cheap and easy to handle catalyst HClO 4 (70 %, aq) was identified as a powerful catalyst for this arylation reaction. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2510 / 2515

页数：6

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