Infection with Helicobacter pylori strains lacking dupA is associated with an increased risk of gastric ulcer and gastric cancer development

被引:42
作者
Abadi, Amin Talebi Bezmin [2 ]
Taghvaei, Tarang [3 ]
Wolfram, Lutz [4 ]
Kusters, Johannes G. [1 ]
机构
[1] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht, Netherlands
[2] Tarbiat Modares Univ, Sch Med Sci, Dept Med Bacteriol, Tehran, Iran
[3] Mazandaran Univ Med Sci, Fac Med, Dept Internal Med, Sari, Iran
[4] Univ Zurich Hosp, Dept Internal Med, Div Gastroenterol, Zurich, Switzerland
关键词
GASTRODUODENAL DISEASES; DUODENAL-ULCER; PROMOTING GENE; IMMUNE-RESPONSE; IRAN; VIRULENCE; NORTH; PATHOGENESIS; POPULATION; CHINA;
D O I
10.1099/jmm.0.027052-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Recently, dupA was reported as a new virulence factor in Helicobacter pylori, but its association with gastroduodenal disorders and its mode of action are still unclear. Here, an association of the dupA status with different disease groups was determined and a biological explanation for the observed associations was tested. In total, 216 H. pylori isolates were obtained from 232 presumed H. pylori-infected patients. A positive association was observed between the occurrence of duodenal ulcer (DU) and the presence of dupA [odds ratio (OR) 24.2; 95% confidence interval (Cl) 10.6-54.8]. In addition, an inverse association between the occurrence of gastric cancer (GC) [OR 0.16; 95% Cl 0.05-0.47] and gastric ulcer (GU) [OR 0.34; 95% Cl 0.16-0.68] with the presence of dupA was observed. A putative explanation for the observed associations might be a more corpus-located infection (pan-gastritis) by the dupA-positive strains due to their increased acid resistance. Indeed, a strong association between dupA-positive H. pylori isolated from gastritis patients and in vitro acid resistance was observed (P<0.05). The observed higher acid resistance of the dupA-positive strains suggests that these strains are adapted to a stomach with high gastric acid output. This may in part explain the observed associations, as an increased gastric acid output is thought to be typical for an antrum-predominant H. pylori infection and, whilst this is associated with an increased risk of DU formation, it also decreases the risk for the genesis of GUs and GC.
引用
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页码:23 / 30
页数:8
相关论文
共 32 条
[1]   Antibiotic Resistance of Helicobacter pylori in Mazandaran, North of Iran [J].
Abadi, Amin Talebi Bezmin ;
Mobarez, Ashraf M. ;
Taghvaei, Tarang ;
Wolfram, Lutz .
HELICOBACTER, 2010, 15 (06) :505-509
[2]  
Abadi AT, 2009, J MAZAND U MED SCI, V19, P26
[3]   Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population [J].
Arachchi, H. S. Jayasinghe ;
Kalra, Vijay ;
Lal, Banwari ;
Bhatia, Vikram ;
Baba, C. S. ;
Chakravarthy, S. ;
Rohatgi, S. ;
Sarma, Priyangshu M. ;
Mishra, V. ;
Das, Bimal ;
Ahuja, Vineet .
HELICOBACTER, 2007, 12 (06) :591-597
[4]   The presence of dupA in helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America [J].
Argent, Richard H. ;
Burette, Alain ;
Deyi, Veronique Y. Miendje ;
Atherton, John C. .
CLINICAL INFECTIOUS DISEASES, 2007, 45 (09) :1204-1206
[5]   The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases [J].
Atherton, John C. .
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2006, 1 (01) :63-96
[6]   Identification of loci essential for the growth of Helicobacter pylori under acidic conditions [J].
Bijlsma, JJE ;
Lie-A-Ling, M ;
Nootenboom, IC ;
Vandenbroucke-Grauls, CMJE ;
Kusters, JG .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (05) :1566-1569
[7]   Helicobacter pylori virulence and genetic geography [J].
Covacci, A ;
Telford, JL ;
Del Giudice, G ;
Parsonnet, J ;
Rappuoli, R .
SCIENCE, 1999, 284 (5418) :1328-1333
[8]   Helicobacter pylori in Health and Disease [J].
Cover, Timothy L. ;
Blaser, Martin J. .
GASTROENTEROLOGY, 2009, 136 (06) :1863-1873
[9]   Classification and grading of gastritis - The updated Sydney System [J].
Dixon, MF ;
Genta, RM ;
Yardley, JH ;
Correa, P ;
Batts, KP ;
Dahms, BB ;
Filipe, MI ;
Haggitt, RC ;
Haot, J ;
Hui, PK ;
Lechago, J ;
Lewin, K ;
Offerhaus, JA ;
Price, AB ;
Riddell, RH ;
Sipponen, P ;
Solcia, E ;
Watanabe, H .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (10) :1161-1181
[10]   dupA as a risk determinant in Helicobacter pylori infection [J].
Douraghi, Masoumeh ;
Mohammadi, Marjan ;
Oghalaie, Akbar ;
Abdirad, Afshin ;
Mohagheghi, Mohammad Ali ;
Hosseini, Mahmoud Eshagh ;
Zeraati, Hojat ;
Ghasemi, Amir ;
Esmaieli, Maryam ;
Mohajerani, Nazanin .
JOURNAL OF MEDICAL MICROBIOLOGY, 2008, 57 (05) :554-562