Abdominal aortic calcification in young adult survivors of childhood acute lymphoblastic leukemia: Results from the St. Jude Lifetime Cohort study

被引：13

作者：

Gurney, James G. ^{[1
]}

Ojha, Rohit P. ^{[1
]}

Ness, Kirsten K. ^{[1
]}

Huang, Sujuan ^{[1
]}

Sharma, Shelly ^{[2
]}

Robison, Leslie L. ^{[1
]}

Hudson, Melissa M. ^{[3
]}

Kaste, Sue C. ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Radiol Sci, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 07期

关键词：

adverse late effects; bone mineral density; cancer; cardiovascular disease; epidemiology; metabolic syndrome; BONE-MINERAL DENSITY; FOLLOW-UP GUIDELINES; METABOLIC SYNDROME; CANCER; RISK; MORBIDITY;

D O I：

10.1002/pbc.24134

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abdominal aortic calcification (AAC), metabolic syndrome, and low bone mineral density (BMD) are risk factors for atherosclerotic disease and cardiovascular morbidity. We evaluated AAC in 662 adult survivors of childhood ALL (median age 31 years). AAC was present in 10% of subjects, metabolic syndrome in 36%, and low BMD in 29%. The adjusted odds ratio (OR) for AAC among women with metabolic syndrome was 2.3 (95% CL?=?1.0, 4.3). The adjusted OR for AAC in men with low BMD was 3.1 (95% CL?=?1.3, 7.3). A substantial proportion of adult survivors of childhood ALL have AAC and/or metabolic syndrome, suggestive of early atherosclerotic disease. Pediatr Blood Cancer 2012; 59: 13071309. (C) 2012 Wiley Periodicals, Inc.

引用

页码：1307 / 1309

页数：3

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