Selective Castration-resistant Prostate Cancer Photothermal Ablation With Copper Sulfide Nanoplates

被引：5

作者：

Chen, Jun ^{[1
,3
]}

Wang, Zhao-jie ^{[2
]}

Zhang, Kai-le ^{[1
,3
]}

Xu, Yan-jun

Chen, Zhi-gang ^{[2
]}

Hu, Xiao-yong ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Urol, Yishan Rd 600, Shanghai 200233, Peoples R China

[2] Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai, Peoples R China

[3] Shanghai Eastern Inst Urol Repair & Reconstruct, Shanghai, Peoples R China

来源：

UROLOGY | 2019年 / 125卷

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

INCREASED SURVIVAL; AUTOPHAGY; AGENT; CELLS; NANOPARTICLES; STATISTICS;

D O I：

10.1016/j.urology.2018.11.020

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To explore new therapies for castration-resistant prostate cancer to improve patients' quality of life and extend life. MATERIALS AND METHODS The synthesis, morphology analysis, phase analysis, spectral analysis, and photothermal conversion test were referenced to our previous articles. Then near-infrared light-driven copper sulfide (CuS) nanoplates to inhibit the growth of prostate cancer cells in vivo and in vitro was carried out. Transmission electron microscope, mCherry-LC3 syncytial virus labeling, acridine orange staining, and autophagy protein were used to detect the autophagy caused by CuS nanoplates and chloroquine was used to inhibit the process of autophagy. RESULTS The CuS nanoplates prepared in this study feature low cytotoxicity, simple preparation, and high photothermal conversion efficiency. Driven by 980 nm near-infrared light, CuS nanoplates could inhibit the growth of prostate cancer cells in vivo and in vitro, while triggering the autophagy and cytoprotection of prostate cancer cells. CONCLUSION CuS nanoplates are a kind of commendable photothermal therapy agent in castration-resistant prostate cancer treating. Autophagy inhibition enhances the photothermal efficiency of CuS nanoplates, which indicates favorable application prospects in the treatment of advanced prostate cancer. (C) 2018 Elsevier Inc.

引用

页码：248 / 255

页数：8

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