Jaspine B (pachastrissamine) and 2-epi-jaspine B:: synthesis and structural assignment

被引：59
作者：
Abraham, Elin [1 ]
Davies, Stephen G. [1 ]
Roberts, Paul M. [1 ]
Russell, Angela J. [1 ]
Thomson, James E. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 09期
关键词：
D O I：
10.1016/j.tetasy.2008.04.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Jaspine B (pachastrissamine), which was isolated in 2002 is a naturally occurring anhydrophytosphingosine which displays polutent biological activity, and as such has attracted much attention from synthetic chemists in recent years, with 14 syntheses reported, to date. This review delineates the isolation of jaspine B, and laboratory total syntheses of jaspine B, 2-epi-jaspine B and analogues, which serves to confirm their structure and stereochemistry. (C) 2008 Elsevier Ltd. All rights reserved.
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页码：1027 / 1047
页数：21
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