Cytotoxic lignans from Viburnum foetidum

被引：13

作者：

Li, Hong ^{[1
]}

Luo, Yuanguo ^{[1
]}

Ma, Yan ^{[1
]}

Zeng, Jun ^{[1
]}

Zhang, Xu ^{[1
]}

Wang, Dong ^{[1
]}

Hu, Chunlin ^{[1
]}

机构：

[1] 181 Hosp PLA, Dept Anesthesiol, Guilin 541002, Guangxi Provinc, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 10期

关键词：

Viburnum foetidum; Caprifliaceae; Lignans; Cytotoxicity; AWABUKI;

D O I：

10.1007/s12272-013-0218-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new lignans, 3,4,4'-trihydroxy-3',9-dimethoxy-9,9'-epoxylignan (1), 3,4'-dihydroxy-3',4, 9-trimethoxy-9,9'-epoxylignan (2), together with one known compound, 4,4'-dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan (3), were isolated from the 95 % EtOH extract of Viburnum foetidum. The structures of the two new compounds were elucidated on the basis of 1D, 2D-NMR, and mass spectral analysis. All the lignans were in vitro evaluated for their cytotoxic activities against four tumor cell lines (A549, SK-OV-3, SKMEL-2 and HCT15).

引用

页码：1211 / 1214

页数：4

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