Promoter Hypermethylation of the Phosphatase DUSP22 Mediates PKA- Dependent TAU Phosphorylation and CREB Activation in Alzheimer's Disease

被引：89
作者：
Vicente Sanchez-Mut, Jose [1 ]
Aso, Ester [2 ]
Heyn, Holger [1 ]
Matsuda, Tadashi [3 ]
Bock, Christoph [4 ]
Ferrer, Isidre [2 ]
Esteller, Manel [1 ,5 ,6 ]
机构：
[1] Bellvitge Biomed Res Inst IDIBELL, Epigenet & Biol Program PEBC, Barcelona, Spain
[2] Univ Barcelona, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Hosp Univ Bellvitge, Neuropathol Inst,Bellvitge Biomed Res Inst IDIBEL, Barcelona, Catalonia, Spain
[3] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Immunol, Sapporo, Hokkaido, Japan
[4] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1010 Vienna, Austria
[5] Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Catalonia, Spain
[6] Inst Catalana Recerca & Estudis Avancats, Barcelona, Catalonia, Spain
来源：
HIPPOCAMPUS | 2014年 / 24卷 / 04期
关键词：
epigenetics; DNA methylation; hippocampus; brain and neurodegeneration; ELEMENT-BINDING PROTEIN; DNA METHYLATION; EPIGENETIC MODIFICATIONS; FRONTAL-CORTEX; MICE LACKING; EXPRESSION; NEURONS; TRANSCRIPTION; DEGENERATION; MECHANISMS;
D O I：
10.1002/hipo.22245
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genetic screening in Alzheimer's disease (AD) has identified only a handful of genes that are mutated in the disorder. Thus, for a very large proportion of patients, the biology of their disease is poorly understood. Epigenetic alterations may provide an explanation in these cases. Using DNA methylation profiles of human hippocampus from controls and patients, we have identified the presence of promoter hypermethylation of the dual-specificity phosphatase 22 (DUSP22) gene in AD. DUSP22 is a likely candidate gene for involvement in the pathogenesis of the disorder since, as we demonstrate here, it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling. (c) 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
引用
收藏
页码：363 / 368
页数：6
相关论文
共 27 条
  • [1] cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum
    Andersson, M
    Konradi, C
    Cenci, MA
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (24) : 9930 - 9943
  • [2] Genome-Wide DNA Methylation Differences Between Late-Onset Alzheimer's Disease and Cognitively Normal Controls in Human Frontal Cortex
    Bakulski, Kelly M.
    Dolinoy, Dana C.
    Sartor, Maureen A.
    Paulson, Henry L.
    Konen, John R.
    Lieberman, Andrew P.
    Albin, Roger L.
    Hu, Howard
    Rozek, Laura S.
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2012, 29 (03) : 571 - 588
  • [3] Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
    Bertram, Lars
    Tanzi, Rudolph E.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2008, 9 (10) : 768 - 778
  • [4] Genome-wide DNA methylation profiling using Infinium® assay
    Bibikova, Marina
    Le, Jennie
    Barnes, Bret
    Saedinia-Melnyk, Shadi
    Zhou, Lixin
    Shen, Richard
    Gunderson, Kevin L.
    [J]. EPIGENOMICS, 2009, 1 (01) : 177 - 200
  • [5] The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway
    Chen, AJ
    Zhou, GS
    Juan, T
    Colicos, SM
    Cannon, JP
    Cabriera-Hansen, M
    Meyer, CF
    Jurecic, R
    Copeland, NG
    Gilbert, DJ
    Jenkins, NA
    Fletcher, F
    Tan, TH
    Belmont, JW
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) : 36592 - 36601
  • [6] β-amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors:: In vitro and in vivo mechanisms related to Alzheimer's disease
    Dineley, KT
    Westerman, M
    Bui, D
    Bell, K
    Ashe, KH
    Sweatt, JD
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (12) : 4125 - 4133
  • [7] β-Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1
    Espana, Judit
    Valero, Jorge
    Minano-Molina, Alfredo J.
    Masgrau, Roser
    Martin, Elsa
    Guardia-Laguarta, Cristina
    Lleo, Alberto
    Gimenez-Llort, Lydia
    Rodriguez-Alvarez, Jose
    Saura, Carlos A.
    [J]. JOURNAL OF NEUROSCIENCE, 2010, 30 (28) : 9402 - 9410
  • [8] An anatomically comprehensive atlas of the adult human brain transcriptome
    Hawrylycz, Michael J.
    Lein, Ed S.
    Guillozet-Bongaarts, Angela L.
    Shen, Elaine H.
    Ng, Lydia
    Miller, Jeremy A.
    van de lagemaat, Louie N.
    Smith, Kimberly A.
    Ebbert, Amanda
    Riley, Zackery L.
    Abajian, Chris
    Beckmann, Christian F.
    Bernard, Amy
    Bertagnolli, Darren
    Boe, Andrew F.
    Cartagena, Preston M.
    Chakravarty, M. Mallar
    Chapin, Mike
    Chong, Jimmy
    Dalley, Rachel A.
    Daly, Barry David
    Dang, Chinh
    Datta, Suvro
    Dee, Nick
    Dolbeare, Tim A.
    Faber, Vance
    Feng, David
    Fowler, David R.
    Goldy, Jeff
    Gregor, Benjamin W.
    Haradon, Zeb
    Haynor, David R.
    Hohmann, John G.
    Horvath, Steve
    Howard, Robert E.
    Jeromin, Andreas
    Jochim, Jayson M.
    Kinnunen, Marty
    Lau, Christopher
    Lazarz, Evan T.
    Lee, Changkyu
    Lemon, Tracy A.
    Li, Ling
    Li, Yang
    Morris, John A.
    Overly, Caroline C.
    Parker, Patrick D.
    Parry, Sheana E.
    Reding, Melissa
    Royall, Joshua J.
    [J]. NATURE, 2012, 489 (7416) : 391 - 399
  • [9] What turns CREB on?
    Johannessen, M
    Delghandi, MP
    Moens, U
    [J]. CELLULAR SIGNALLING, 2004, 16 (11) : 1211 - 1227
  • [10] Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB
    Lonze, BE
    Riccio, A
    Cohen, S
    Ginty, DD
    [J]. NEURON, 2002, 34 (03) : 371 - 385
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