Effects of octreotide therapy in progressive head and neck paragangliomas: Case series

被引：19
作者：
van Hulsteijn, Leonie T. [1 ]
van Duinen, Nicolette [1 ]
Verbist, Berit M. [2 ]
Jansen, Jeroen C. [3 ]
van der Klaauw, Agatha A. [1 ]
Smit, Jan W. A. [1 ,4 ]
Corssmit, Eleonora P. M. [1 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ, Med Ctr, Dept Radiol, NL-2300 RC Leiden, Netherlands
[3] Leiden Univ, Med Ctr, Dept Otorhinolaryngol, NL-2300 RC Leiden, Netherlands
[4] Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, NL-6525 ED Nijmegen, Netherlands
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2013年 / 35卷 / 12期
关键词：
octreotide; head and neck paragangliomas; somatostatin analogues; tumor growth; treatment; SOMATOSTATIN ANALOGS; NEUROENDOCRINE TUMORS; CARCINOID-SYNDROME; GROWTH; MUTATIONS; PHEOCHROMOCYTOMA; PROLIFERATION; MANAGEMENT; EXCRETION; APOPTOSIS;
D O I：
10.1002/hed.23348
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundOctreotide, a somatostatin analog, may be beneficial in the treatment of head and neck paragangliomas (HNPGLs). MethodsWe conducted a nonblinded, prospective intervention study. During 1 year, patients received a monthly intramuscular injection of 30 mg octreotide. Pretreatment and posttreatment tumor volumes were assessed by MRI, urinary catecholamine secretion was measured, and HNPGL-related signs and symptoms were recorded. ResultsIn 1 of 4 included patients with HNPGL, a stabilization of tumor growth was observed after octreotide therapy. In 1 patient, octreotide therapy was discontinued before the end of the study because of potential side effects. No improvements in HNPGL-related signs and symptoms were observed. ConclusionIn 1 of 4 patients, HNPGL tumor growth velocity was reduced after octreotide therapy. Research assessing the effects of somatostatin analogues targeting different somatostatin receptor subtypes or combined with other therapies may offer new possibilities for the treatment of HNPGLs. (c) 2013 Wiley Periodicals, Inc. Head Neck 35: E391-E396, 2013
引用
收藏
页码：E391 / E396
页数：6
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