α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties

被引：1
|
作者：
Quintero, Cirley [1 ]
Vera, Ricardo [1 ]
Dario Perez, Leon [2 ]
机构：
[1] Pontificia Univ Javeriana, Dept Quim, Bogota, DC, Colombia
[2] Univ Nacl Colombia UNAL, Dept Quim, Grp Macromol, Bogota, DC, Colombia
来源：
POLIMEROS-CIENCIA E TECNOLOGIA | 2016年 / 26卷 / 04期
关键词：
alpha-tocopherol; polycaprolactone; thermosensitive nanoparticles; triblock copolymer; ENCAPSULATION; MICELLES; ABTS; PCL;
D O I：
10.1590/0104-1428.2324
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
alpha-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of alpha-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core - shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of alpha-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.
引用
收藏
页码：304 / 312
页数：9
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