Intracerebral Hematoma Contributes to Hydrocephalus After Intraventricular Hemorrhage via Aggravating Iron Accumulation

被引:92
作者
Chen, Qianwei [1 ]
Tang, Jun [1 ]
Tan, Liang [1 ]
Guo, Jing [1 ]
Tao, Yihao [1 ]
Li, Lin [1 ]
Chen, Yujie [1 ]
Liu, Xin [1 ]
Zhang, John H. [2 ]
Chen, Zhi [1 ]
Feng, Hua [1 ]
机构
[1] Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing 400038, Peoples R China
[2] Loma Linda Univ, Dept Anesthesia Neurosurg & Physiol, Loma Linda, CA 92350 USA
基金
中国国家自然科学基金;
关键词
brain injuries; cerebral hemorrhage; cerebrospinal fluid; hydrocephalus; iron; GERMINAL MATRIX HEMORRHAGE; BRAIN-INJURY; GROWTH-FACTOR; RAT MODEL; POSTHEMORRHAGIC HYDROCEPHALUS; VENTRICULAR EXTENSION; INHIBITION; HEMOGLOBIN; MECHANISMS; ADULTS;
D O I
10.1161/STROKEAHA.115.009713
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose The intraventricular hemorrhage (IVH) secondary to intracerebral hemorrhage (ICH) was reported to be relevant to a higher incidence of hydrocephalus, which would result in poorer outcomes for patients with ICH. However, the mechanisms responsible for this relationship remain poorly characterized. Thus, this study was designed to further explore the development and progression of hydrocephalus after secondary IVH. Methods Autologous blood injection model was induced to mimic ICH with ventricular extension (ICH/IVH) or primary IVH in Sprague-Dawley rats. Magnetic resonance imaging, Morris water maze, brain water content, Evans blue extravasation, immunohistochemistry staining, Western blot, iron determination, and electron microscopy were used in these rats. Then, deferoxamine treatment was used to clarify the involvement of iron in the development of hydrocephalus. Results Despite the injection of equivalent blood volumes, ICH/IVH resulted in more significant ventricular dilation, ependymal cilia damage, and iron overload, as well as more severe early brain injury and neurological deficits compared with IVH alone. Systemic deferoxamine treatment more effectively reduced ventricular enlargement in ICH/IVH compared with primary IVH. Conclusions Our results show that ICH/IVH caused more significant chronic hydrocephalus and iron accumulation than primary IVH alone. Intracerebral hematoma plays a vital role in persistent iron overload and aggravated hydrocephalus after ICH/IVH.
引用
收藏
页码:2902 / 2908
页数:7
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