Bifunctional Photocatalysts for Enantioselective Aerobic Oxidation of β-Ketoesters

被引：220

作者：

Ding, Wei ^{[1
]}

Lu, Liang-Qiu ^{[1
]}

Quan-Quan Zhou ^{[1
]}

Wei, Yi ^{[1
]}

Chen, Jia-Rong ^{[1
]}

Xiao, Wen-Jing ^{[1
]}

机构：

[1] Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PHOTOREDOX CATALYSIS; ALPHA-HYDROXYLATION; DUAL-CATALYSIS; KETO-ESTERS; COOPERATIVE PHOTOREDOX; ASYMMETRIC-SYNTHESIS; MERGING PHOTOREDOX; BRONSTED ACID; ATOM-TRANSFER; ALKYLATION;

D O I：

10.1021/jacs.6b11418

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel visible-light-responsive chiral ligand has been developed by grafting a triplet state photo sensitizer to chiral bisoxazoline ligands. Complexation of this ligand with Ni(acac)(2) results in a powerful catalyst for the asymmetric oxidation reaction of beta-ketoesters, which uses oxygen or air as the green oxidant and visible light or sunlight as the ideal driving force. Using this protocol, products containing the alpha-hydroxy-beta-dicarbonyl motif are produced in high yields and with excellent enantiopurities.

引用

页码：63 / 66

页数：4

共 77 条

[1] Organocatalytic asymmetric hydroxylation of β-keto esters:: Metal-free synthesis of optically active anti-diols [J].