Infections and the development of allergy

被引:57
作者
Holt, PG
机构
关键词
allergy; T helper cells; cytokines; infection; immunocompetence; infancy;
D O I
10.1016/0378-4274(96)03692-2
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The development of resistance or sensitivity to environmental antigens depends to a large extent on the nature of immunological memory which is generated during early antigen encounters in infancy and early childhood. The latter involves antigen-driven selection for specific Th-l-like versus Th-2-like memory cells within individual immune responses to inhaled allergens, a process which occurs in the regional lymph nodes (RLN) draining the conducting airways and which is regulated by a variety of cytokines produced by antigen-specific CD4(+) and CD8(+) T-cells. In addition, this T-cell selection process can theoretically be influenced by infectious agents, at two distinct levels. Firstly, infections in the airway mucosa may mobilise and activate local tissue macrophages, which migrate to RLN and secrete Th-2-inhibitory cytokines such as IL-12 and IFN alpha, and also add to IFN gamma levels in the milieu via stimulation of NK cells. Secondly, microbial stimulation via gastrointestinal tract (GIT) commensals and pathogens is recognised as the principal trigger for postnatal maturation of overall immune competence in mammals. Recent studies indicate that the speed with which the immune system in human infants attains adult-equivalent competence postnatally is inversely related to 'risk' for primary allergic sensitisation to environmental antigens. Factors which affect qualitative/quantitative aspects of microbial colonisation of the GIT during early postnatal life may accordingly have unexpected downstream effects on seemingly unrelated processes such as development of T cell memory to allergens.
引用
收藏
页码:205 / 210
页数:6
相关论文
共 26 条
[1]   DISTINCT TYPES OF LUNG-DISEASE CAUSED BY FUNCTIONAL SUBSETS OF ANTIVIRAL T-CELLS [J].
ALWAN, WH ;
KOZLOWSKA, WJ ;
OPENSHAW, PJM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (01) :81-89
[2]   RISK-FACTORS IN EARLY-CHILDHOOD FOR THE DEVELOPMENT OF ATOPIC DISEASES [J].
BJORKSTEN, B .
ALLERGY, 1994, 49 (06) :400-407
[3]   ROLE AND CONTRIBUTION OF VIRAL RESPIRATORY-INFECTIONS TO ASTHMA [J].
BUSSE, WW .
ALLERGY, 1993, 48 (17) :57-61
[4]  
DEVEY ME, 1993, CLIN EXP IMMUNOL, V94, P117, DOI 10.1111/j.1365-2249.1993.tb05987.x
[5]  
Hattevig G, 1993, Pediatr Allergy Immunol, V4, P182, DOI 10.1111/j.1399-3038.1993.tb00089.x
[6]  
HOL PG, 1992, CLIN EXP ALLERGY, V22, P1093
[7]   INDUCTION OF ADJUVANT-INDEPENDENT IGE RESPONSES IN INBRED MICE - PRIMARY, SECONDARY, AND PERSISTENT IGE RESPONSES TO OVALBUMIN AND OVOMUCOID [J].
HOLT, PG ;
ROSE, AH ;
BATTY, JE ;
TURNER, KJ .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1981, 65 (01) :42-50
[8]  
HOLT PG, 1987, IMMUNOLOGY, V60, P97
[9]   DEFENSE AGAINST ALLERGIC SENSITIZATION IN THE HEALTHY LUNG - THE ROLE OF INHALATION TOLERANCE [J].
HOLT, PG ;
MCMENAMIN, C .
CLINICAL AND EXPERIMENTAL ALLERGY, 1989, 19 (03) :255-262
[10]   IMMUNOPROPHYLAXIS OF ATOPY - LIGHT AT THE END OF THE TUNNEL [J].
HOLT, PG .
IMMUNOLOGY TODAY, 1994, 15 (10) :484-489