Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population

被引:6
作者
Ghersel, Frederico Rezende [1 ]
Souto, Ricardo Peres [1 ]
Pacheco Gonzales, Ester Wilma [1 ]
Paulo, Denise Souza [1 ]
Eduardo Fernandes, Cesar [1 ]
Oliveira, Emerson [1 ]
机构
[1] Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
来源
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA | 2019年 / 41卷 / 03期
基金
巴西圣保罗研究基金会;
关键词
polymorphism; matrix metalloproteinase; pelvic organ prolapse; EXPRESSION; SUPPORT; TISSUE;
D O I
10.1055/s-0039-1681112
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identify the clinical variables associated with the occurrence of the disease. Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be involved. Methods Cohort study with 86 women with symptomatic POP (cases), and 158 women without a prior or current diagnosis of this disorder (controls). The groups were analyzed for the presence of MMP9 gene polymorphisms. Genotyping was performed using polymerase chain reaction (PCR) with DNA obtained from a peripheral venous puncture of both groups. Results There were no differences between the cases and controls even when we grouped the mutant homozygous and heterozygous genotypes. The analysis of patients with a complete absence of POP versus patients with total POP also showed no statistically significant differences. Age and home birth were found to be independent risk factors for POP. Conclusions There were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases and controls in Brazilian women.
引用
收藏
页码:164 / 169
页数:6
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