Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population
被引:6
作者:
Ghersel, Frederico Rezende
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h-index: 0
机构:
Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, BrazilFac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
Ghersel, Frederico Rezende
[1
]
Souto, Ricardo Peres
论文数: 0引用数: 0
h-index: 0
机构:
Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, BrazilFac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
Souto, Ricardo Peres
[1
]
Pacheco Gonzales, Ester Wilma
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h-index: 0
机构:
Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, BrazilFac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
Pacheco Gonzales, Ester Wilma
[1
]
Paulo, Denise Souza
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h-index: 0
机构:
Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, BrazilFac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
Paulo, Denise Souza
[1
]
Eduardo Fernandes, Cesar
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h-index: 0
机构:
Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, BrazilFac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
Eduardo Fernandes, Cesar
[1
]
Oliveira, Emerson
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h-index: 0
机构:
Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, BrazilFac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
Oliveira, Emerson
[1
]
机构:
[1] Fac Med ABC, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Ave Lauro Gomes,2000, BR-09060870 Santo Andre, SP, Brazil
来源:
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
|
2019年
/
41卷
/
03期
基金:
巴西圣保罗研究基金会;
关键词:
polymorphism;
matrix metalloproteinase;
pelvic organ prolapse;
EXPRESSION;
SUPPORT;
TISSUE;
D O I:
10.1055/s-0039-1681112
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Objective To evaluate the C-1562T matrix metalloproteinase 9 (MMP9) gene polymorphisms as risk factors related to the occurrence of pelvic organ prolapse (POP) and to identify the clinical variables associated with the occurrence of the disease. Epidemiological studies of risk factors for POP do not explain why nulliparous women with no known risk factors also develop POP. Therefore, genetic factors may be involved. Methods Cohort study with 86 women with symptomatic POP (cases), and 158 women without a prior or current diagnosis of this disorder (controls). The groups were analyzed for the presence of MMP9 gene polymorphisms. Genotyping was performed using polymerase chain reaction (PCR) with DNA obtained from a peripheral venous puncture of both groups. Results There were no differences between the cases and controls even when we grouped the mutant homozygous and heterozygous genotypes. The analysis of patients with a complete absence of POP versus patients with total POP also showed no statistically significant differences. Age and home birth were found to be independent risk factors for POP. Conclusions There were no statistically significant differences in the C-1562T MMP9 polymorphisms between the cases and controls in Brazilian women.
机构:
China Med Univ, Grad Inst Integrated Med, China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Chen, Huey-Yi
Lin, Wei-Yong
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Grad Inst Integrated Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Lin, Wei-Yong
Chen, Yung-Hsiang
论文数: 0引用数: 0
h-index: 0
机构:China Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Chen, Yung-Hsiang
Chen, Wen-Chi
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Grad Inst Integrated Med, China Med Univ Hosp, Dept Urol, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Chen, Wen-Chi
Tsai, Fuu-Jen
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Tsai, Fuu-Jen
Tsai, Chang-Hai
论文数: 0引用数: 0
h-index: 0
机构:
Asia Univ, Taichung, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Ganj, Farnaz A.
Ibeanu, Okechukwu A.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Ibeanu, Okechukwu A.
Bedestani, Ahmet
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Bedestani, Ahmet
Nolan, Thomas E.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Nolan, Thomas E.
Chesson, Ralph R.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
机构:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USA
Gill, EJ
Hurt, WG
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USA
机构:
Univ New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, AustraliaUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Haylen, Bernard T.
Maher, Christopher F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Brisbane, Qld, AustraliaUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Maher, Christopher F.
Barber, Matthew D.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Cleveland, OH 44106 USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Barber, Matthew D.
Camargo, Sergio
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Presidente Varga, Porto Alegre, RS, BrazilUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Camargo, Sergio
Dandolu, Vani
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nevada, Las Vegas, NV 89154 USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Dandolu, Vani
Digesu, Alex
论文数: 0引用数: 0
h-index: 0
机构:
St Marys Hosp, London, EnglandUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Digesu, Alex
Goldman, Howard B.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Cleveland, OH 44106 USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Goldman, Howard B.
Huser, Martin
论文数: 0引用数: 0
h-index: 0
机构:
Brno Univ Hosp, Brno, Czech RepublicUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Huser, Martin
Milani, Alfredo L.
论文数: 0引用数: 0
h-index: 0
机构:
Reinier De Graaf Gasthuis, Delft, NetherlandsUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Milani, Alfredo L.
Moran, Paul A.
论文数: 0引用数: 0
h-index: 0
机构:
Worcestershire Royal Hosp, Worcester, MA USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Moran, Paul A.
Schaer, Gabriel. N.
论文数: 0引用数: 0
h-index: 0
机构:
Kantonsspital, Aarau, SwitzerlandUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Schaer, Gabriel. N.
Withagen, Mariella I. J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Utrecht, NetherlandsUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
机构:
China Med Univ, Grad Inst Integrated Med, China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Chen, Huey-Yi
Lin, Wei-Yong
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Grad Inst Integrated Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Lin, Wei-Yong
Chen, Yung-Hsiang
论文数: 0引用数: 0
h-index: 0
机构:China Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Chen, Yung-Hsiang
Chen, Wen-Chi
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Grad Inst Integrated Med, China Med Univ Hosp, Dept Urol, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Chen, Wen-Chi
Tsai, Fuu-Jen
论文数: 0引用数: 0
h-index: 0
机构:
China Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
Tsai, Fuu-Jen
Tsai, Chang-Hai
论文数: 0引用数: 0
h-index: 0
机构:
Asia Univ, Taichung, TaiwanChina Med Univ, Sch Chinese Med, China Med Univ Hosp, Dept Med Genet, Taichung 404, Taiwan
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Ganj, Farnaz A.
Ibeanu, Okechukwu A.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Ibeanu, Okechukwu A.
Bedestani, Ahmet
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Bedestani, Ahmet
Nolan, Thomas E.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
Nolan, Thomas E.
Chesson, Ralph R.
论文数: 0引用数: 0
h-index: 0
机构:
Louisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USALouisiana State Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, New Orleans, LA 70112 USA
机构:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USA
Gill, EJ
Hurt, WG
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USAVirginia Commonwealth Univ, Med Coll Virginia, Dept Obstet & Gynecol, Richmond, VA 23298 USA
机构:
Univ New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, AustraliaUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Haylen, Bernard T.
Maher, Christopher F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Queensland, Brisbane, Qld, AustraliaUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Maher, Christopher F.
Barber, Matthew D.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Cleveland, OH 44106 USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Barber, Matthew D.
Camargo, Sergio
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Presidente Varga, Porto Alegre, RS, BrazilUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Camargo, Sergio
Dandolu, Vani
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nevada, Las Vegas, NV 89154 USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Dandolu, Vani
Digesu, Alex
论文数: 0引用数: 0
h-index: 0
机构:
St Marys Hosp, London, EnglandUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Digesu, Alex
Goldman, Howard B.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Cleveland, OH 44106 USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Goldman, Howard B.
Huser, Martin
论文数: 0引用数: 0
h-index: 0
机构:
Brno Univ Hosp, Brno, Czech RepublicUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Huser, Martin
Milani, Alfredo L.
论文数: 0引用数: 0
h-index: 0
机构:
Reinier De Graaf Gasthuis, Delft, NetherlandsUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Milani, Alfredo L.
Moran, Paul A.
论文数: 0引用数: 0
h-index: 0
机构:
Worcestershire Royal Hosp, Worcester, MA USAUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Moran, Paul A.
Schaer, Gabriel. N.
论文数: 0引用数: 0
h-index: 0
机构:
Kantonsspital, Aarau, SwitzerlandUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia
Schaer, Gabriel. N.
Withagen, Mariella I. J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr, Utrecht, NetherlandsUniv New S Wales, St Vincents Clin, Suite 904,438 Victoria St, Darlinghurst, NSW 2010, Australia